Betts, MJ;
Ehrenberg, AJ;
Hämmerer, D;
Düzel, E;
(2018)
Commentary: Locus Coeruleus Ablation Exacerbates Cognitive Deficits, Neuropathology, and Lethality in P301S Tau Transgenic Mice.
Frontiers in Neuroscience
, 12
, Article 401. 10.3389/fnins.2018.00401.
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Abstract
A commentary on: Locus Coeruleus Ablation Exacerbates Cognitive Deficits, Neuropathology, and Lethality in P301S Tau Transgenic Mice by Chalermpalanupap, T., Schroeder, J. P., Rorabaugh, J. M., Liles, L. C., Lah, J. J., Levey, A. I., et al. (2018). J. Neurosci. 38, 74–92. doi: 10.1523/JNEUROSCI.1483-17.2017. Alzheimer's disease (AD) is characterized by progressive neuron loss as well as the accumulation of neurofibrillary tangles, otherwise referred to as tau pathology, and β-amyloid plaques. Second to neuron loss, tau pathology is the best predictor of cognitive decline in AD. Recently, tau pathology onset in the locus coeruleus (LC) has been shown to consistently precede cortical tau pathology and increase in severity along Braak staging.
| Type: | Article |
|---|---|
| Title: | Commentary: Locus Coeruleus Ablation Exacerbates Cognitive Deficits, Neuropathology, and Lethality in P301S Tau Transgenic Mice |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.3389/fnins.2018.00401 |
| Publisher version: | https://doi.org/10.3389/fnins.2018.00401 |
| Language: | English |
| Additional information: | © 2018 Betts, Ehrenberg, Hämmerer and Düzel. This is an open-access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). |
| Keywords: | locus coeruleus, norepinephrine, hippocampus, tauopathy, learning and memory, neuropathology |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Institute of Cognitive Neuroscience |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10051501 |
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