Skoog, I;
Kern, S;
Zetterberg, H;
Ostling, S;
Borjesson-Hanson, A;
Guo, X;
Blennow, K;
(2018)
Low Cerebrospinal Fluid A beta(42) and A beta(40) are Related to White Matter Lesions in Cognitively Normal Elderly.
Journal of Alzheimer's Disease
, 62
(4)
pp. 1877-1886.
10.3233/JAD-170950.
Preview |
Text
jad%2F2018%2F62-4%2Fjad-62-4-jad170950%2Fjad-62-jad170950.pdf - Published Version Download (95kB) | Preview |
Abstract
Background: Low cerebrospinal fluid (CSF) levels of Aβ42 may be the earliest manifestation of Alzheimer’s disease (AD). Knowledge on how CSF Aβ interacts with different brain pathologies early in the disease process is limited. We examined how CSF Aβ markers relate to brain atrophy and white matter lesions (WMLs) in octogenarians with and without dementia to explore the earliest pathogenetic pathways of AD in the oldest old. // Objective: To study CSF amyloid biomarkers in relation to brain atrophy and WMLs in 85-year-olds with and without dementia. // Methods: 53 octogenarians took part in neuropsychiatric examinations and underwent both a lumbar puncture and a brain CT scan. CSF levels of Aβ42 and Aβ40 were examined in relation to cerebral atrophy and WMLs. Dementia was diagnosed. // Results: In 85-year-olds without dementia, lower levels of both CSF Aβ42 and CSF Aβ40 were associated with WMLs. CSF Aβ42 also correlated with measures of central atrophy, but not with cortical atrophy. In participants with dementia, lower CSF levels of Aβ42 were related to frontal, temporal, and parietal cortical atrophy but not to WMLs. // Conclusions: Our findings may suggest that there is an interrelationship between Aβ and subcortical WMLs in older persons without dementia. After onset of dementia, low CSF Aβ42, probably representing amyloid deposition in plaques, is associated with cortical atrophy. WMLs may be an earlier manifestation of Aβ deposition than cortical degeneration.
| Type: | Article |
|---|---|
| Title: | Low Cerebrospinal Fluid A beta(42) and A beta(40) are Related to White Matter Lesions in Cognitively Normal Elderly |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.3233/JAD-170950 |
| Publisher version: | http://dx.doi.org/10.3233/JAD-170950 |
| Language: | English |
| Additional information: | Copyright © 2018 IOS Press and the authors. This article is published online with Open Access and distributed under the terms of the Creative Commons Attribution Non-Commercial License (CC BY-NC 4.0) (https://creativecommons.org/licenses/by-nc/4.0/). |
| Keywords: | Alzheimer’s disease, amyloid-, biomarkers, cerebrospinal fluid, computerized tomography, dementia, epidemiological methods, population-based, vascular dementia, white matter lesions |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10051243 |
Archive Staff Only
 |
View Item |
