Negrete-Diaz, JV;
Sihra, TS;
Flores, G;
Rodriguez-Moreno, A;
(2018)
Non-canonical Mechanisms of Presynaptic Kainate Receptors Controlling Glutamate Release.
Frontiers in Molecular Neuroscience
, 11
, Article 128. 10.3389/fnmol.2018.00128.
Preview |
Text
Non-canonical Mechanisms of Presynaptic Kainate Receptors Controlling Glutamate Release.pdf - Published Version Download (1MB) | Preview |
Abstract
A metabotropic modus operandi for kainate receptors (KARs) was first discovered in 1998 modulating GABA release. These receptors have been also found to modulate glutamate release at different synapses in several brain regions. Mechanistically, a general biphasic mechanism for modulating glutamate release by presynaptic KARs with metabotropic actions has emerged, with low KA concentrations invoking an increase in glutamate release, whereas higher concentrations of KA mediate a decrease in the release of this neurotransmitter. The molecular mechanisms underpinning the opposite modulation of glutamate release are distinct, with a G-protein-independent, adenylate cyclase (AC)- and protein kinase A (PKA)-dependent mechanism mediating the facilitation of glutamate release, while a G-protein dependent mechanism (with or without protein kinase recruitment) is involved in the decrease of neurotransmitter release. In the present review, we revisit the mechanisms underlying the non-canonical modus operandi of KARs effecting the bimodal control of glutamatergic transmission in different brain regions, and address the possible functions that this modulation may support.
| Type: | Article |
|---|---|
| Title: | Non-canonical Mechanisms of Presynaptic Kainate Receptors Controlling Glutamate Release |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.3389/fnmol.2018.00128 |
| Publisher version: | https://doi.org/10.3389/fnmol.2018.00128 |
| Language: | English |
| Additional information: | This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Neurosciences, Neurosciences & Neurology, metabotropic, kainate receptors, presynaptic, glutamate, G protein, protein kinase A, protein kinase C, MOSSY-FIBER SYNAPSES, LONG-TERM DEPRESSION, EXCITATORY SYNAPTIC-TRANSMISSION, PROTEIN-KINASE-A, GATED ION CHANNELS, RAT HIPPOCAMPUS, THALAMOCORTICAL SYNAPSES, MEDIATED FACILITATION, ADENYLYL CYCLASES, METABOTROPIC FUNCTION |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Neuro, Physiology and Pharmacology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10051207 |
Loading...
Loading...Loading...Loading...Archive Staff Only
 |
View Item |
