Amiri, H;
de Sitter, A;
Bendfeldt, K;
Battaglini, M;
Gandini Wheeler-Kingshott, CAM;
Calabrese, M;
Geurts, JJG;
... Vrenken, H; + view all
(2018)
Urgent challenges in quantification and interpretation of brain grey matter atrophy in individual MS patients using MRI.
NeuroImage: Clinical
, 19
pp. 466-475.
10.1016/j.nicl.2018.04.023.
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Abstract
Atrophy of the brain grey matter (GM) is an accepted and important feature of multiple sclerosis (MS). However, its accurate measurement is hampered by various technical, pathological and physiological factors. As a consequence, it is challenging to investigate the role of GM atrophy in the disease process as well as the effect of treatments that aim to reduce neurodegeneration. In this paper we discuss the most important challenges currently hampering the measurement and interpretation of GM atrophy in MS. The focus is on measurements that are obtained in individual patients rather than on group analysis methods, because of their importance in clinical trials and ultimately in clinical care. We discuss the sources and possible solutions of the current challenges, and provide recommendations to achieve reliable measurement and interpretation of brain GM atrophy in MS.
| Type: | Article |
|---|---|
| Title: | Urgent challenges in quantification and interpretation of brain grey matter atrophy in individual MS patients using MRI |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.nicl.2018.04.023 |
| Publisher version: | https://doi.org/10.1016/j.nicl.2018.04.023 |
| Language: | English |
| Additional information: | This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
| Keywords: | Multiple sclerosis, Brain atrophy, Grey matter, Magnetic resonance imaging |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Brain Repair and Rehabilitation UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neuroinflammation |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10050968 |
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