Martínez-Poles, J;
Nedkova-Hristova, V;
Escribano-Paredes, JB;
García-Madrona, S;
Natera-Villalba, E;
Estévez-Fraga, C;
López-Sendón Moreno, JL;
... Alonso-Canovas, A; + view all
(2018)
Incobotulinumtoxin A for Sialorrhea in Neurological Disorders: A Real-Life Experience.
Toxins
, 10
(6)
, Article 217. 10.3390/toxins10060217.
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Abstract
Botulinum toxin type A is one of the most useful treatments of sialorrhea in neurological disorders. Evidence for the use of incobotulinumtoxin A (inco-A) in the treatment of sialorrhea is limited. Thirty-six patients with sialorrhea were treated with infiltrations of inco-A into both parotid glands. The severity of sialorrhea was evaluated by the Drooling Severity Scale (DSS), and the Drooling Frequency Scale (DFS). Patients' perceptions of clinical benefit were recorded via the Patient Global Impression of Improvement (PGI-I) scale. Following treatment, there was a significant difference in both the DFS and the DSS (p < 0.001). Clinical benefits on the basis of the PGI-I were present in up to 90% of patients.
| Type: | Article |
|---|---|
| Title: | Incobotulinumtoxin A for Sialorrhea in Neurological Disorders: A Real-Life Experience. |
| Location: | Switzerland |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.3390/toxins10060217 |
| Publisher version: | https://doi.org/10.3390/toxins10060217 |
| Language: | English |
| Additional information: | This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0). |
| Keywords: | Parkinson’s disease, botulinum toxin type A, incobotulinumtoxin A, neurological disorders, sialorrhea |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10050833 |
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