Wainwright, EN;
Scaffidi, P;
(2017)
Epigenetics and Cancer Stem Cells: Unleashing, Hijacking, and Restricting Cellular Plasticity.
Trends in cancer
, 3
(5)
pp. 372-386.
10.1016/j.trecan.2017.04.004.
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Abstract
Epigenetic regulators are one of the most commonly mutated classes of genes in cancer. During cancer initiation, mutated epigenetic regulators lead to oncogenic cellular reprogramming and promote the acquisition of uncontrolled self-renewal. The emergence of CSCs requires elaborate reorganization of the epigenome. During cancer growth, epigenetic mechanisms integrate the effect of cell-intrinsic (i.e., subclonal mutations) and cell-extrinsic (i.e., signaling from the microenvironment) changes and establish intratumoral heterogeneity, either promoting or inhibiting the CSC state. ‘Loose’ epigenetic constraints in cancer cells enhance cellular plasticity and allow reversible transitions between different phenotypic states. Enhanced cellular plasticity favors cancer cell adaptability and resistance to therapy. Modulation of epigenetic processes allows targeting of the most downstream determinants of the CSC state.
| Type: | Article |
|---|---|
| Title: | Epigenetics and Cancer Stem Cells: Unleashing, Hijacking, and Restricting Cellular Plasticity |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.trecan.2017.04.004 |
| Publisher version: | https://doi.org/10.1016/j.trecan.2017.04.004 |
| Language: | English |
| Additional information: | © 2017 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Oncology, Acute Myeloid-Leukemia, Acute Lymphoblastic-Leukemia, Self-Renewal, Breast-Cancer, Therapeutic Target, H3K79 Methylation, Melanoma-Cells, Solid Tumors, Rnai Screen, Lung-Cancer |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10050817 |
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