Mudera, C;
Torii, R;
Hodgson, D;
Velliou, R;
(2018)
Modelling multi-scale cell-tissue interaction of tissue-engineered muscle constructs.
Journal of Tissue Engineering
, 9
pp. 1-9.
10.1177/2041731418787141.
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Abstract
Expectation on engineered tissue substitute continues to grow and for an effective development of a functional tissue and to control its quality, cellular mehcanoresponse plays a key role. Although the mechanoresponse – in terms of cell-tissue interaction across scales – has been understood better in recent years, there are still technical limitations to quantitatively monitor the processes involved in the development of both native and engineered tissues. Computational (in silico) studies have been utilised to complement the experimental limitations and successfully applied to prediction of tissue growth. We here review recent activities in the area of combined experimental and computational analyses of tissue growth, especially in tissue-engineering context, and highlight the advantages of such an approach for the future of the tissue engineering, using our own case study of predicting musculoskeletal tissue-engineering construct development.
| Type: | Article |
|---|---|
| Title: | Modelling multi-scale cell-tissue interaction of tissue-engineered muscle constructs |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1177/2041731418787141 |
| Publisher version: | https://doi.org/10.1177/2041731418787141 |
| Language: | English |
| Additional information: | Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Mechanical Engineering |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10050133 |
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