Lange, F;
Dunne, L;
Hale, L;
Tachtsidis, I;
(2019)
MAESTROS: A multi-wavelength time domain NIRS system to monitor changes in oxygenation and oxidation state of cytochrome-c-oxidase.
IEEE Journal of Selected Topics in Quantum Electronics
, 25
(1)
, Article 7100312. 10.1109/JSTQE.2018.2833205.
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Abstract
CCBY We present a multi-wavelength, multi-channel, time domain near-infrared spectroscopy (NIRS) system named MAESTROS. This instrument can measure absorption and scattering coefficients and can quantify the concentrations of oxy- and deoxy-haemoglobin ([HbO2] , [HHb]), and oxidation state of cytochrome-c-oxidase ([oxCCO] ). This system is composed of a supercontinuum laser source coupled with two acousto-optic tuneable filters (AOTF). The light is collected by four photomultipliers tubes (PMT), connected to a router to redirect the signal to a single TCSPC card. The interface between the system and the tissue is based on optical fibres. This arrangement allows us to resolve up to sixteen wavelengths, within the range of 650 to 900 nm, at a sampling rate compatible with the physiology (from 0.5 to 2 Hz). In this paper, we describe the system and assess its performance based on two specifically designed protocols for photon migration instruments, the BIP and nEUROPt protocols, and on a well characterized liquid phantom based on Intralipid and water. Then, the ability to resolve [HbO2], [HHb] and [oxCCO] is demonstrated on a homogeneous liquid phantom, based on blood for [HbO2] , [HHb] and yeast for [oxCCO] . In the future, the system could be used to monitor brain tissue physiology.
| Type: | Article |
|---|---|
| Title: | MAESTROS: A multi-wavelength time domain NIRS system to monitor changes in oxygenation and oxidation state of cytochrome-c-oxidase |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1109/JSTQE.2018.2833205 |
| Publisher version: | http://dx.doi.org/10.1109/JSTQE.2018.2833205 |
| Language: | English |
| Additional information: | This work is licensed under a Creative Commons Attribution 3.0 License. For more information, see http://creativecommons.org/licenses/by/3.0/. |
| Keywords: | Time domain measurements, Spectroscopy, Biomedical engineering, Laser biomedical applications, Photomultipliers, Scattering |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Electronic and Electrical Eng UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10049711 |
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