Wray, NR;
Ripke, S;
Mattheisen, M;
Trzaskowski, M;
Byrne, EM;
Abdellaoui, A;
Adams, MJ;
... Sullivan, PF; + view all
(2018)
Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression.
Nature Genetics
, 50
(5)
pp. 668-681.
10.1038/s41588-018-0090-3.
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Abstract
Major depressive disorder (MDD) is a common illness accompanied by considerable morbidity, mortality, costs, and heightened risk of suicide. We conducted a genome-wide association meta-analysis based in 135,458 cases and 344,901 controls and identified 44 independent and significant loci. The genetic findings were associated with clinical features of major depression and implicated brain regions exhibiting anatomical differences in cases. Targets of antidepressant medications and genes involved in gene splicing were enriched for smaller association signal. We found important relationships of genetic risk for major depression with educational attainment, body mass, and schizophrenia: lower educational attainment and higher body mass were putatively causal, whereas major depression and schizophrenia reflected a partly shared biological etiology. All humans carry lesser or greater numbers of genetic risk factors for major depression. These findings help refine the basis of major depression and imply that a continuous measure of risk underlies the clinical phenotype.
| Type: | Article |
|---|---|
| Title: | Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1038/s41588-018-0090-3 |
| Publisher version: | https://doi.org/10.1038/s41588-018-0090-3 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Genetics & Heredity, LD SCORE REGRESSION, BODY-MASS INDEX, MENDELIAN RANDOMIZATION, EDUCATIONAL-ATTAINMENT, SYSTEMATIC ANALYSIS, MENTAL-DISORDERS, POLYGENIC RISK, EUROPE 2010, LOCI, METAANALYSIS |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Division of Psychiatry |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10049546 |
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