Pruefer, K;
de Filippo, C;
Grote, S;
Mafessoni, F;
Korlevic, P;
Hajdinjak, M;
Vernot, B;
... Paabo, S; + view all
(2017)
A high-coverage Neandertal genome from Vindija Cave in Croatia.
Science
, 358
(6363)
pp. 655-658.
10.1126/science.aao1887.
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Abstract
To date, the only Neandertal genome that has been sequenced to high quality is from an individual found in Southern Siberia. We sequenced the genome of a female Neandertal from ~50,000 years ago from Vindija Cave, Croatia, to ~30-fold genomic coverage. She carried 1.6 differences per 10,000 base pairs between the two copies of her genome, fewer than present-day humans, suggesting that Neandertal populations were of small size. Our analyses indicate that she was more closely related to the Neandertals that mixed with the ancestors of present-day humans living outside of sub-Saharan Africa than the previously sequenced Neandertal from Siberia, allowing 10 to 20% more Neandertal DNA to be identified in present-day humans, including variants involved in low-density lipoprotein cholesterol concentrations, schizophrenia, and other diseases.
| Type: | Article |
|---|---|
| Title: | A high-coverage Neandertal genome from Vindija Cave in Croatia |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1126/science.aao1887 |
| Publisher version: | https://doi.org/10.1126/science.aao1887 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Science & Technology, Multidisciplinary Sciences, Science & Technology - Other Topics, MODERN HUMANS, ADMIXTURE, SEQUENCE, ANCIENT, DNA, INTROGRESSION, POPULATIONS, ANCESTRY |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Genetics, Evolution and Environment |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10048104 |
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