Schmitz, N; Deschenes, SS; Burns, RJ; Danna, SM; Franco, OH; Ikram, MA; Kivimaki, M; ... Tiemeier, H; + view all Schmitz, N; Deschenes, SS; Burns, RJ; Danna, SM; Franco, OH; Ikram, MA; Kivimaki, M; Singh-Manoux, A; Tiemeier, H; - view fewer (2018) Cardiometabolic dysregulation and cognitive decline: potential role of depressive symptoms. The British Journal of Psychiatry , 212 (2) pp. 96-102. 10.1192/bjp.2017.26.

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Abstract

INTRODUCTION: BACKGROUND: Previous studies have examined associations of cardiometabolic factors with depression and cognition separately. AIMS: To determine if depressive symptoms mediate the association between cardiometabolic factors and cognitive decline in two community studies. METHOD: Data for the analyses were drawn from the Rotterdam Study, the Netherlands (n = 2940) and the Whitehall II study, UK (n = 4469). RESULTS: Mediation analyses suggested a direct association between cardiometabolic factors and cognitive decline and an indirect association through depression: poorer cardiometabolic status at time 1 was associated with a higher level of depressive symptoms at time 2 (standardised regression coefficient 0.07 and 0.06, respectively), which, in turn, was associated with greater cognitive decline between time 2 and time 3 (standardised regression coefficient of −0.15 and −0.41, respectively). CONCLUSIONS: Evidence from two independent cohort studies suggest an association between cardiometabolic dysregulation and cognitive decline and that depressive symptoms tend to precede this decline

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