Schmitz, N;
Deschenes, SS;
Burns, RJ;
Danna, SM;
Franco, OH;
Ikram, MA;
Kivimaki, M;
... Tiemeier, H; + view all
(2018)
Cardiometabolic dysregulation and cognitive decline: potential role of depressive symptoms.
The British Journal of Psychiatry
, 212
(2)
pp. 96-102.
10.1192/bjp.2017.26.
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Abstract
INTRODUCTION: BACKGROUND: Previous studies have examined associations of cardiometabolic factors with depression and cognition separately. AIMS: To determine if depressive symptoms mediate the association between cardiometabolic factors and cognitive decline in two community studies. METHOD: Data for the analyses were drawn from the Rotterdam Study, the Netherlands (n = 2940) and the Whitehall II study, UK (n = 4469). RESULTS: Mediation analyses suggested a direct association between cardiometabolic factors and cognitive decline and an indirect association through depression: poorer cardiometabolic status at time 1 was associated with a higher level of depressive symptoms at time 2 (standardised regression coefficient 0.07 and 0.06, respectively), which, in turn, was associated with greater cognitive decline between time 2 and time 3 (standardised regression coefficient of −0.15 and −0.41, respectively). CONCLUSIONS: Evidence from two independent cohort studies suggest an association between cardiometabolic dysregulation and cognitive decline and that depressive symptoms tend to precede this decline
| Type: | Article |
|---|---|
| Title: | Cardiometabolic dysregulation and cognitive decline: potential role of depressive symptoms |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1192/bjp.2017.26 |
| Publisher version: | https://doi.org/10.1192/bjp.2017.26 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Psychiatry, Increased Risk, Metabolic Syndrome, Whitehall-II, Dementia, Disease, Metaanalysis, Association, Disorders, Cohort, Components |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health > Epidemiology and Public Health |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10047747 |
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