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Diabetes mellitus and latent tuberculosis infection: baseline analysis of a large UK cohort

Jackson, C; Southern, J; Lalvani, A; Drobniewski, F; Griffiths, CJ; Lipman, M; Bothamley, GH; ... Abubakar, I; + view all (2018) Diabetes mellitus and latent tuberculosis infection: baseline analysis of a large UK cohort. Thorax , 74 (1) pp. 91-94. 10.1136/thoraxjnl-2017-211124. Green open access

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Abstract

We conducted a cross-sectional analysis of baseline data from a UK cohort study which enrolled participants at risk of latent tuberculosis infection (LTBI, defined as a positive result for either of the two interferon gamma release assays). Binomial regression with a log link was used to estimate crude and adjusted prevalence ratios (PRs) and 95% CIs for the relationship between diabetes mellitus (DM) and LTBI. Adjusted for age, sex, ethnicity, body mass index and the presence of other immunocompromising conditions, DM was associated with a 15% higher prevalence of LTBI (adjusted PR=1.15, 95%CI 1.02 to 1.30, p=0.025).

Type: Article
Title: Diabetes mellitus and latent tuberculosis infection: baseline analysis of a large UK cohort
Open access status: An open access version is available from UCL Discovery
DOI: 10.1136/thoraxjnl-2017-211124
Publisher version: https://doi.org/10.1136/thoraxjnl-2017-211124
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Respiratory Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology > MRC Clinical Trials Unit at UCL
URI: https://discovery.ucl.ac.uk/id/eprint/10047561
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