Jackson, C; Southern, J; Lalvani, A; Drobniewski, F; Griffiths, CJ; Lipman, M; Bothamley, GH; ... Abubakar, I; + view all Jackson, C; Southern, J; Lalvani, A; Drobniewski, F; Griffiths, CJ; Lipman, M; Bothamley, GH; Deeks, JJ; Imran, A; Kon, OM; Mpofu, S; Nikolayevskyy, V; Rees-Roberts, M; Sitch, A; Sridhar, S; Tsou, C-Y; Whitworth, H; Abubakar, I; - view fewer (2018) Diabetes mellitus and latent tuberculosis infection: baseline analysis of a large UK cohort. Thorax , 74 (1) pp. 91-94. 10.1136/thoraxjnl-2017-211124.

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Abstract

We conducted a cross-sectional analysis of baseline data from a UK cohort study which enrolled participants at risk of latent tuberculosis infection (LTBI, defined as a positive result for either of the two interferon gamma release assays). Binomial regression with a log link was used to estimate crude and adjusted prevalence ratios (PRs) and 95% CIs for the relationship between diabetes mellitus (DM) and LTBI. Adjusted for age, sex, ethnicity, body mass index and the presence of other immunocompromising conditions, DM was associated with a 15% higher prevalence of LTBI (adjusted PR=1.15, 95%CI 1.02 to 1.30, p=0.025).

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