Salvado, DSAS;
(2018)
Development of a Practical Calibration Procedure for a Clinical SPECT/MRI System Using a Single INSERT Prototype Detector and Multi-Mini Slit-Slat Collimator.
IEEE Transactions on Radiation and Plasma Medical Sciences
, 2
(4)
10.1109/TRPMS.2018.2828163.
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Abstract
In the context of the INSERT project, we have been developing a clinical SPECT insert for an MRI system, in order to perform simultaneous SPECT/MRI of the human brain. This system will consist of 20 CsI:Tl scintillation detectors, 5 cm wide and 10 cm long, with a 72-channel SiPM readout per detector, and a multi-mini slit-slat (MSS) collimator set up in a stationary partial ring. Additionally the system has a custom-built transmit/receive MR coil to ensure compatibility with the SPECT system. Due to the novel design of the system/collimator, existing geometric calibration methods are not suitable. Therefore we propose a novel and practical calibration procedure that consists of a set of specific independent measurements to determine the geometric parameters of the collimator. This procedure was developed utilising a prototype system that consists of a reduced-size single detector with a 36-channel SiPM-based readout and a single MSS collimator module. Validation was performed by reconstructing different imaging phantoms, using a rotating stage to simulate a tomographic acquisition. Regarding uniformity, the COV for the cylinder phantom reconstructed with correct calibration parameters is 6.7%, whereas the COV using incorrect parameters is 9.4%. The quality of the phantom reconstructions provide evidence of the applicability of the proposed method to the calibration of the prototype system. This procedure can be easily adapted for the final INSERT system.
| Type: | Article |
|---|---|
| Title: | Development of a Practical Calibration Procedure for a Clinical SPECT/MRI System Using a Single INSERT Prototype Detector and Multi-Mini Slit-Slat Collimator |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1109/TRPMS.2018.2828163 |
| Publisher version: | http://doi.org/10.1109/TRPMS.2018.2828163 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Practical calibration, prototype system, INSERT |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Department of Imaging |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10047437 |
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