Quigley, MA;
Carson, C;
Kelly, Y;
(2018)
Breastfeeding And Childhood Wheeze: Age-Specific Analyses And Longitudinal Wheezing Phenotypes As Complimentary Approaches To The Analysis Of Cohort Data.
American Journal of Epidemiology
, 187
(8)
pp. 1651-1661.
10.1093/aje/kwy057.
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Abstract
Systematic reviews suggest that breastfeeding is associated with a lower risk of asthma, although marked heterogeneity exists. Using UK Millennium Cohort Study data (n = 10,126 children born 2000-2001), we examined the association between breastfeeding duration and wheezing in the past year, first at each age-group separately (age 9 months, 3, 5, 7 and 11 years) and then as a longitudinal wheezing phenotype: 'early transient' (wheezing any time up to age 5 but not thereafter); 'late onset' (any time from age 7 but not beforehand); 'persistent' (any time up to age 5 and any time from age 7). The association between breastfeeding and wheeze varied by age (interaction two-sided P = 0.0003). For example, breastfeeding for 6-9 months was associated with lower odds of wheezing at age 9 months, 3, and 5 years, but less so at age 7 and 11 years (adjusted odds ratios 0.73, 0.78, 0.79, 0.84, 1.06 respectively). There was a strong dose response relationship for breastfeeding per month and early transient wheeze (adjusted linear trend OR 0.961, 95% CI: 0.942, 0.980), but no clear trend for late onset or persistent wheeze. Our results identified heterogeneity in the association between breastfeeding and wheezing according to age at wheezing and wheezing phenotype.
| Type: | Article |
|---|---|
| Title: | Breastfeeding And Childhood Wheeze: Age-Specific Analyses And Longitudinal Wheezing Phenotypes As Complimentary Approaches To The Analysis Of Cohort Data |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1093/aje/kwy057 |
| Publisher version: | http://doi.org/10.1093/aje/kwy057 |
| Language: | English |
| Additional information: | © The Author(s) 2018. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journalpermissions@oup.com. |
| Keywords: | Breastfeeding, asthma, wheeze, phenotype, longitudinal, Millennium Cohort Study |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health > Epidemiology and Public Health |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10047047 |
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