Rothman, JE;
Krishnakumar, SS;
Grushin, K;
Pincet, F;
(2017)
Hypothesis - buttressed rings assemble, clamp, and release SNAREpins for synaptic transmission.
FEBS Letters
, 591
(21)
pp. 3459-3480.
10.1002/1873-3468.12874.
Preview |
Text
feb212874.pdf - Published Version Download (1MB) | Preview |
Abstract
Neural networks are optimized to detect temporal coincidence on the millisecond timescale. Here, we offer a synthetic hypothesis based on recent structural insights into SNAREs and the C2 domain proteins to explain how synaptic transmission can keep this pace. We suggest that an outer ring of up to six curved Munc13 ‘MUN’ domains transiently anchored to the plasma membrane via its flanking domains surrounds a stable inner ring comprised of synaptotagmin C2 domains to serve as a work-bench on which SNAREpins are templated. This ‘buttressed-ring hypothesis’ affords straightforward answers to many principal and long-standing questions concerning how SNAREpins can be assembled, clamped, and then released synchronously with an action potential.
| Type: | Article |
|---|---|
| Title: | Hypothesis - buttressed rings assemble, clamp, and release SNAREpins for synaptic transmission |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1002/1873-3468.12874 |
| Publisher version: | http://doi.org/10.1002/1873-3468.12874 |
| Language: | English |
| Additional information: | Copyright © 2017 The Authors. FEBS Letters published by John Wiley & Sons Ltd 3459 on behalf of Federation of European Biochemical Societies. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
| Keywords: | membrane fusion; SNARE ; synaptic transmission |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Experimental Epilepsy |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10044915 |
Archive Staff Only
 |
View Item |
