Roy, M;
Sorokina, O;
Skene, N;
Simonnet, C;
Mazzo, F;
Zwart, R;
Sher, E;
... Grant, SGN; + view all
(2018)
Proteomic analysis of postsynaptic proteins in regions of the human neocortex.
Nature Neuroscience
, 21
(1)
pp. 130-138.
10.1038/s41593-017-0025-9.
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Abstract
The postsynaptic proteome of excitatory synapses comprises ~1,000 highly conserved proteins that control the behavioral repertoire, and mutations disrupting their function cause >130 brain diseases. Here, we document the composition of postsynaptic proteomes in human neocortical regions and integrate it with genetic, functional and structural magnetic resonance imaging, positron emission tomography imaging, and behavioral data. Neocortical regions show signatures of expression of individual proteins, protein complexes, biochemical and metabolic pathways. We characterized the compositional signatures in brain regions involved with language, emotion and memory functions. Integrating large-scale GWAS with regional proteome data identifies the same cortical region for smoking behavior as found with fMRI data. The neocortical postsynaptic proteome data resource can be used to link genetics to brain imaging and behavior, and to study the role of postsynaptic proteins in localization of brain functions.
| Type: | Article |
|---|---|
| Title: | Proteomic analysis of postsynaptic proteins in regions of the human neocortex |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1038/s41593-017-0025-9 |
| Publisher version: | http://doi.org/10.1038/s41593-017-0025-9 |
| Language: | English |
| Additional information: | © 2017 Nature America Inc., part of Springer Nature. All rights reserved. This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Neurosciences, Neurosciences & Neurology, GENOME-WIDE ASSOCIATION, 38 SUSCEPTIBILITY LOCI, HUMAN BRAIN, QUANTITATIVE-ANALYSIS, AEROBIC GLYCOLYSIS, ALZHEIMERS-DISEASE, NMDA RECEPTOR, RAT FOREBRAIN, R PACKAGE, SCHIZOPHRENIA |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10044778 |
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