Schrouff, J;
Perlbarg, V;
Boly, M;
Marrelec, G;
Boveroux, P;
Vanhaudenhuyse, A;
Bruno, M-A;
... Benali, H; + view all
(2011)
Brain functional integration decreases during propofol-induced loss of consciousness.
NeuroImage
, 57
(1)
pp. 198-205.
10.1016/j.neuroimage.2011.04.020.
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Abstract
Consciousness has been related to the amount of integrated information that the brain is able to generate. In this paper, we tested the hypothesis that the loss of consciousness caused by propofol anesthesia is associated with a significant reduction in the capacity of the brain to integrate information. To assess the functional structure of the whole brain, functional integration and partial correlations were computed from fMRI data acquired from 18 healthy volunteers during resting wakefulness and propofol-induced deep sedation. Total integration was significantly reduced from wakefulness to deep sedation in the whole brain as well as within and between its constituent networks (or systems). Integration was systematically reduced within each system (i.e., brain or networks), as well as between networks. However, the ventral attentional network maintained interactions with most other networks during deep sedation. Partial correlations further suggested that functional connectivity was particularly affected between parietal areas and frontal or temporal regions during deep sedation. Our findings suggest that the breakdown in brain integration is the neural correlate of the loss of consciousness induced by propofol. They stress the important role played by parietal and frontal areas in the generation of consciousness. Research highlights ► Detection of low frequency fMRI group networks using sICA and clustering. ► Objective, automatic methods to quantify interactions between networks. ► Comparison of resting wakefulness and propofol-induced anesthesia using integration. ► Significant decreases in within- and between-network integration at the brain scale. ► Fronto-parietal segregation of networks during sedation.
| Type: | Article |
|---|---|
| Title: | Brain functional integration decreases during propofol-induced loss of consciousness |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.neuroimage.2011.04.020 |
| Publisher version: | http://dx.doi.org/10.1016/j.neuroimage.2011.04.020 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Neurosciences, Neuroimaging, Radiology, Nuclear Medicine & Medical Imaging, Neurosciences & Neurology, Anesthesia, Propofol, Networks, Connectivity, Quantification, Integration, ALZHEIMERS-DISEASE, DEFAULT-MODE, CONNECTIVITY, HUMANS, FMRI, MRI, METABOLISM, ANESTHESIA, STATE |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Computer Science |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10043765 |
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