Kapata, N;
Grobusch, MP;
Chongwe, G;
Chanda-Kapata, P;
Ngosa, W;
Tembo, M;
Musonda, S;
... Cobelens, F; + view all
(2017)
Outcomes of multidrug-resistant tuberculosis in Zambia: a cohort analysis.
Infection
, 45
(6)
pp. 831-839.
10.1007/s15010-017-1054-8.
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Abstract
PURPOSE: The purpose of this study was to establish a baseline for measuring the impact of the programmatic management of drug-resistant TB program by following up on outcomes of all patients diagnosed with multidrug-resistant tuberculosis in Zambia between 2012 and 2014. METHODS: A cohort study of all the MDR-TB patients diagnosed at the national TB reference laboratory from across Zambia. MDR-TB was diagnosed by culture and DST, whereas outcome data were collected in 2015 by patient record checks and home visits. RESULTS: The total number of patients diagnosed was 258. Of those, 110 (42.6%) patients were traceable for this study. There were 67 survivor participants (60.9%); 43 (39.1%) were deceased. Out of the 110 patients who were traced, only 71 (64.5%) were started on second-line treatment. Twenty-nine (40.8%) patients were declared cured and 16.9% were still on treatment; 8.4% had failed treatment. The survival rate was 20.2 per 100 person-years of follow-up. Taking ARVs was associated with a decreased risk of dying (hazard ratio 0.12, p = 0.002). Sex, age, marital status and treatment category were not important predictors of survival in MDR-TB patients. CONCLUSIONS: More than half of the patients diagnosed with MDR-TB were lost to follow-up before second-line treatment was initiated.
| Type: | Article |
|---|---|
| Title: | Outcomes of multidrug-resistant tuberculosis in Zambia: a cohort analysis |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1007/s15010-017-1054-8 |
| Publisher version: | http://dx.doi.org/10.1007/s15010-017-1054-8 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Infectious Diseases, Zambia, Tuberculosis, MDR-TB, Drug resistance, Treatment outcome, HIGH TREATMENT SUCCESS, SOUTH-AFRICA, OBSERVATIONAL COHORT, DRUG-RESISTANCE, FOLLOW-UP, HIV, METAANALYSIS, CHILDREN, DEFAULT |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10042619 |
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Loading...Loading...| 1. |  Zambia | 19 |
| 2. |  United States | 8 |
| 3. |  China | 5 |
| 4. |  Indonesia | 2 |
| 5. |  Pakistan | 1 |
| 6. |  Uganda | 1 |
| 7. |  Korea, Republic of | 1 |
| 8. | ["irstats2_objects:country_code:SS" not defined] | 1 |
| 9. |  Europe | 1 |
| 10. |  Egypt | 1 |
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