Pocratsky, AM;
Burke, DA;
Morehouse, JR;
Beare, JE;
Riegler, AS;
Tsoulfas, P;
States, GJR;
... Magnuson, DSK; + view all
(2017)
Reversible silencing of lumbar spinal interneurons unmasks a task-specific network for securing hindlimb alternation.
Nature Communications
, 8
, Article 1963. 10.1038/s41467-017-02033-x.
Preview |
Text (Published article)
s41467-017-02033-x.pdf - Published Version Download (3MB) | Preview |
Preview |
Text (Supplementary figures and tables)
Pocratsky_Reversible_silencing_lumbar_S1.pdf Download (1MB) | Preview |
Preview |
Text (Peer Review file)
Pocratsky_Reversible_silencing_lumbar_S2.pdf Download (1MB) | Preview |
Preview |
Text (Description of supplementary movie files)
Pocratsky_Reversible_silencing_lumbar_S3.pdf Download (53kB) | Preview |
![[thumbnail of Supplementary Movie 1]](https://discovery.ucl.ac.uk/style/images/fileicons/video.png) |
Video (Supplementary Movie 1)
Pocratsky_Reversible_silencing_lumbar_S4.mp4 Download (1MB) |
|
Video (Supplementary Movie 2)
Pocratsky_Reversible_silencing_lumbar_S5.mp4 Download (1MB) |
Abstract
Neural circuitry in the lumbar spinal cord governs two principal features of locomotion, rhythm and pattern, which reflect intra- and interlimb movement. These features are functionally organized into a hierarchy that precisely controls stepping in a stereotypic, speed-dependent fashion. Here, we show that a specific component of the locomotor pattern can be independently manipulated. Silencing spinal L2 interneurons that project to L5 selectively disrupts hindlimb alternation allowing a continuum of walking to hopping to emerge from the otherwise intact network. This perturbation, which is independent of speed and occurs spontaneously with each step, does not disrupt multi-joint movements or forelimb alternation, nor does it translate to a non-weight-bearing locomotor activity. Both the underlying rhythm and the usual relationship between speed and spatiotemporal characteristics of stepping persist. These data illustrate that hindlimb alternation can be manipulated independently from other core features of stepping, revealing a striking freedom in an otherwise precisely controlled system.
| Type: | Article |
|---|---|
| Title: | Reversible silencing of lumbar spinal interneurons unmasks a task-specific network for securing hindlimb alternation |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1038/s41467-017-02033-x |
| Publisher version: | http://dx.doi.org/10.1038/s41467-017-02033-x |
| Language: | English |
| Additional information: | Copyright © The Author(s) 2017. Open Access: This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/ licenses/by/4.0/. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Department of Neuromuscular Diseases |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10040642 |
Archive Staff Only
 |
View Item |
