Miettinen, TP;
Caldez, MJ;
Kaldis, P;
Bjorklund, M;
(2017)
Cell size control - a mechanism for maintaining fitness and function.
BioEssays
, 39
(9)
, Article 1700058. 10.1002/bies.201700058.
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Abstract
The maintenance of cell size homeostasis has been studied for years in different cellular systems. With the focus on ‘what regulates cell size’, the question ‘why cell size needs to be maintained’ has been largely overlooked. Recent evidence indicates that animal cells exhibit nonlinear cell size dependent growth rates and mitochondrial metabolism, which are maximal in intermediate sized cells within each cell population. Increases in intracellular distances and changes in the relative cell surface area impose biophysical limitations on cells, which can explain why growth and metabolic rates are maximal in a specific cell size range. Consistently, aberrant increases in cell size, for example through polyploidy, are typically disadvantageous to cellular metabolism, fitness and functionality. Accordingly, cellular hypertrophy can potentially predispose to or worsen metabolic diseases. We propose that cell size control may have emerged as a guardian of cellular fitness and metabolic activity.
| Type: | Article |
|---|---|
| Title: | Cell size control - a mechanism for maintaining fitness and function |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1002/bies.201700058 |
| Publisher version: | http://dx.doi.org/10.1002/bies.201700058 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | cell size control; fitness; metabolism; mevalonate pathway; mitochondria; polyploidy; statin |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Lab for Molecular Cell Bio MRC-UCL |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10039687 |
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