Marshall, CR;
Hardy, CJD;
Russell, LL;
Clark, CN;
Dick, KM;
Brotherhood, EV;
Bond, RL;
... Warren, JD; + view all
(2017)
Impaired Interoceptive Accuracy in Semantic Variant Primary Progressive Aphasia.
Frontiers in Neurology
, 8
, Article 610. 10.3389/fneur.2017.00610.
Preview |
Text
fneur-08-00610.pdf - Published Version Available under License : See the attached licence file. Download (294kB) | Preview |
Abstract
Background: Interoception (the perception of internal bodily sensations) is strongly linked to emotional experience and sensitivity to the emotions of others in healthy subjects. Interoceptive impairment may contribute to the profound socioemotional symptoms that characterize frontotemporal dementia (FTD) syndromes, but remains poorly defined. / Methods: Patients representing all major FTD syndromes and healthy age-matched controls performed a heartbeat counting task as a measure of interoceptive accuracy. In addition, patients had volumetric MRI for voxel-based morphometric analysis, and their caregivers completed a questionnaire assessing patients’ daily-life sensitivity to the emotions of others. / Results: Interoceptive accuracy was impaired in patients with semantic variant primary progressive aphasia relative to healthy age-matched individuals, but not in behavioral variant frontotemporal dementia and nonfluent variant primary progressive aphasia. Impaired interoceptive accuracy correlated with reduced daily-life emotional sensitivity across the patient cohort, and with atrophy of right insula, cingulate, and amygdala on voxel-based morphometry in the impaired semantic variant group, delineating a network previously shown to support interoceptive processing in the healthy brain. / Conclusion: Interoception is a promising novel paradigm for defining mechanisms of reduced emotional reactivity, empathy, and self-awareness in neurodegenerative syndromes and may yield objective measures for these complex symptoms.
| Type: | Article |
|---|---|
| Title: | Impaired Interoceptive Accuracy in Semantic Variant Primary Progressive Aphasia |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.3389/fneur.2017.00610 |
| Publisher version: | http://dx.doi.org/10.3389/fneur.2017.00610 |
| Language: | English |
| Additional information: | Copyright © 2017 Marshall, Hardy, Russell, Clark, Dick, Brotherhood, Bond, Mummery, Schott, Rohrer, Kilner and Warren. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (http://creativecommons.org/licenses/by/4.0/). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| Keywords: | interoception, autonomic, cardiac, empathy, primary progressive aphasia, frontotemporal dementia |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10039479 |
Archive Staff Only
 |
View Item |
