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A 32-by-32 CMOS microelectrode array for capacitive biosensing and impedance spectroscopy

Valente, V; Demosthenous, A; (2017) A 32-by-32 CMOS microelectrode array for capacitive biosensing and impedance spectroscopy. In: Circuits and Systems (ISCAS), 2017 IEEE International Symposium on. IEEE: Baltimore, MD, USA. Green open access

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Abstract

This paper presents the design of a 1024-channel dual-modality CMOS biosensor suitable for both capacitive sensing and impedance spectroscopy. The chip serves as a platform for detection, localization and monitoring of bacteria and can be adopted for affinity-based assays. The chip features a 32×32 array of unpassivated metal electrodes formed on the top metal of a 0.18μm CMOS process, with an overall sensing area of 2.06 mm2. The system design is based on a shared in-pixel integrator that can be used as a charge amplifier for capacitive sensing (CS) or as part of a transimpedance amplifier for electrical impedance spectroscopy (EIS). The CS mode is capable of a operation bandwidth of 50 MHz at a current consumption of 82 μA per pixel. The EIS channel operates over a bandwidth between 100 Hz and 1 MHz with a total input-referred current noise of 48 pArms and a current consumption of 210 μA per channel.

Type: Proceedings paper
Title: A 32-by-32 CMOS microelectrode array for capacitive biosensing and impedance spectroscopy
Event: 2017 IEEE International Symposium on Circuits and Systems (ISCAS)
ISBN-13: 9781467368520
Open access status: An open access version is available from UCL Discovery
DOI: 10.1109/ISCAS.2017.8050734
Publisher version: https://doi.org/10.1109/ISCAS.2017.8050734
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Impedance, Capacitors, Spectroscopy, Bandwidth, Sensor arrays, Gain
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Electronic and Electrical Eng
URI: https://discovery.ucl.ac.uk/id/eprint/10039265
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