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Muscle membrane properties in a pig sepsis model: Effect of norepinephrine

Boërio, D; Corrêa, TD; Jakob, SM; Ackermann, KA; Bostock, H; Z'Graggen, WJ; (2018) Muscle membrane properties in a pig sepsis model: Effect of norepinephrine. Muscle & Nerve , 57 (5) pp. 808-813. 10.1002/mus.26013. Green open access

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Abstract

INTRODUCTION: Sepsis-induced myopathy and critical illness myopathy are common causes of muscle weakness in intensive care patients. This study investigated the effect of different mean arterial blood pressure (MAP) levels on muscle membrane properties following experimental sepsis. METHODS: Sepsis was induced with faecal peritonitis in 12 out of 18 anesthetized and mechanically ventilated pigs. Seven were treated with a high (75-85 mm Hg) and 5 with a low (≥60 mm Hg) MAP target for resuscitation. In septic animals, resuscitation was started 12 hours after peritonitis induction, and muscle velocity recovery cycles were recorded 30 hours later. RESULTS: Muscles in the sepsis/high MAP group showed an increased relative refractory period and reduced early supernormality, compared to the remaining septic animals and the control group, indicating membrane depolarization and/or sodium channel inactivation. The membrane abnormalities correlated positively with norepinephrine dose. DISCUSSION: Norepinephrine may contribute to sepsis-induced abnormalities in muscle by impairing microcirculation.

Type: Article
Title: Muscle membrane properties in a pig sepsis model: Effect of norepinephrine
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1002/mus.26013
Publisher version: https://doi.org/10.1002/mus.26013
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: ICU acquired weakness, critical illness myopathy, electromyography, electrophysiology, experimental sepsis, norepinephrine
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
URI: https://discovery.ucl.ac.uk/id/eprint/10037958
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