Boërio, D; Corrêa, TD; Jakob, SM; Ackermann, KA; Bostock, H; Z'Graggen, WJ; (2018) Muscle membrane properties in a pig sepsis model: Effect of norepinephrine. Muscle & Nerve , 57 (5) pp. 808-813. 10.1002/mus.26013.

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Abstract

INTRODUCTION: Sepsis-induced myopathy and critical illness myopathy are common causes of muscle weakness in intensive care patients. This study investigated the effect of different mean arterial blood pressure (MAP) levels on muscle membrane properties following experimental sepsis. METHODS: Sepsis was induced with faecal peritonitis in 12 out of 18 anesthetized and mechanically ventilated pigs. Seven were treated with a high (75-85 mm Hg) and 5 with a low (≥60 mm Hg) MAP target for resuscitation. In septic animals, resuscitation was started 12 hours after peritonitis induction, and muscle velocity recovery cycles were recorded 30 hours later. RESULTS: Muscles in the sepsis/high MAP group showed an increased relative refractory period and reduced early supernormality, compared to the remaining septic animals and the control group, indicating membrane depolarization and/or sodium channel inactivation. The membrane abnormalities correlated positively with norepinephrine dose. DISCUSSION: Norepinephrine may contribute to sepsis-induced abnormalities in muscle by impairing microcirculation.

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