Liu, J;
Li, Z;
Greene, NDE;
Li, H;
Ren, A;
(2017)
The recurrence risk of neural tube defects (NTDs) in a population with high prevalence of NTDs in northern China.
Oncotarget
, 8
(42)
pp. 72577-72583.
10.18632/oncotarget.19890.
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Abstract
BACKGROUND: Although a number of studies have reported the recurrence risk of NTDs in developed countries, there is little data on the rate of recurrence of NTDs in northern China, a region of high prevalence of NTDs. METHODS: Based on the population-based birth defects surveillance system of five counties, we identified women who had an NTD affected pregnancy from 2004-2015 and a retrospective survey was conducted. The rate of recurrence of NTDs was calculated by the number of recurrent NTDs divided by the first NTDs. Maternal age, body mass index (BMI), gestational weeks, education, and occupation were collected. Information on folic acid (FA) supplements, time and dosage were also recorded. RESULTS: Among 851 women who had a previous NTD-affected pregnancy, there were 578 subsequent pregnancies, with 10 recurrent NTDs, a 1.7% recurrence rate. The recurrence rate was 1.5% and 2.6% for those taking FA supplements and without FA supplementation respectively. Women with recurrent NTDs had higher BMI before pregnancy compared to those who had a second pregnancy without NTDs. Among the recurrent NTDs, the majority were spina bifida. CONCLUSIONS: The recurrence rate of NTDs was approximately five times higher than the overall prevalence in the same region of northern China. Risk of recurrence appeared lower among women who took FA supplements. These findings are consistent with the reduction in NTD frequency in the population since introduction of the nationwide FA supplement program. Data on recurrence rates in northern China will inform power calculations for future intervention studies.
| Type: | Article |
|---|---|
| Title: | The recurrence risk of neural tube defects (NTDs) in a population with high prevalence of NTDs in northern China |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.18632/oncotarget.19890 |
| Publisher version: | http://doi.org/10.18632/oncotarget.19890 |
| Language: | English |
| Additional information: | © Liu et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Oncology, Cell Biology, recurrence, neural tube defects, folic acid, supplementation, China, FOLIC-ACID SUPPLEMENTATION, VITAMIN SUPPLEMENTATION, MATERNAL OBESITY, SHANXI PROVINCE, BIRTH-DEFECTS, UNITED-STATES, PREVENTION, SURVEILLANCE, WOMEN, AREA |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Biology and Cancer Dept |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10037711 |
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