Krasnow, AM;
Ford, MC;
Valdivia, LE;
Wilson, SW;
Attwell, D;
(2018)
Regulation of developing myelin sheath elongation by oligodendrocyte calcium transients in vivo.
Nature Neuroscience
, 21
pp. 24-28.
10.1038/s41593-017-0031-y.
Preview |
Text
KrasnowFordValdiviaWilsonAttwell.pdf - Accepted Version Download (3MB) | Preview |
Abstract
How action potentials regulate myelination by oligodendrocytes is uncertain. We show that neuronal activity raises [Ca2+]i in developing oligodendrocytes in vivo and that myelin sheath elongation is promoted by a high frequency of [Ca2+]i transients and prevented by [Ca2+]i buffering. Sheath elongation occurs ~1 h after [Ca2+]i elevation. Sheath shortening is associated with a low frequency of [Ca2+]i transients but with longer duration [Ca2+]i bursts. Thus, [Ca2+]i controls myelin sheath development.
Archive Staff Only
 |
View Item |
