Jun, GR;
Chung, J;
Mez, J;
Barber, R;
Beecham, GW;
Bennett, DA;
Buxbaum, JD;
... Farrer, LA; + view all
(2017)
Transethnic genome-wide scan identifies novel Alzheimer's disease loci.
Alzheimer's & Dementia
, 13
(7)
pp. 727-738.
10.1016/j.jalz.2016.12.012.
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Abstract
INTRODUCTION: Genetic loci for Alzheimer's disease (AD) have been identified in whites of European ancestry, but the genetic architecture of AD among other populations is less understood. METHODS: We conducted a transethnic genome-wide association study (GWAS) for late-onset AD in Stage 1 sample including whites of European Ancestry, African-Americans, Japanese, and Israeli-Arabs assembled by the Alzheimer's Disease Genetics Consortium. Suggestive results from Stage 1 from novel loci were followed up using summarized results in the International Genomics Alzheimer's Project GWAS dataset. RESULTS: Genome-wide significant (GWS) associations in single-nucleotide polymorphism (SNP)–based tests (P < 5 × 10−8) were identified for SNPs in PFDN1/HBEGF, USP6NL/ECHDC3, and BZRAP1-AS1 and for the interaction of the (apolipoprotein E) APOE ε4 allele with NFIC SNP. We also obtained GWS evidence (P < 2.7 × 10−6) for gene-based association in the total sample with a novel locus, TPBG (P = 1.8 × 10−6). DISCUSSION: Our findings highlight the value of transethnic studies for identifying novel AD susceptibility loci.
| Type: | Article |
|---|---|
| Title: | Transethnic genome-wide scan identifies novel Alzheimer's disease loci |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.jalz.2016.12.012 |
| Publisher version: | http://doi.org/10.1016/j.jalz.2016.12.012 |
| Language: | English |
| Additional information: | © 2017 The Authors. Published by Elsevier Inc. on behalf of the Alzheimer’s Association. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Clinical Neurology, Neurosciences & Neurology, Transethnic, Alzheimer's disease, Genome-wide association, APOE interaction, APOLIPOPROTEIN-E GENOTYPE, SUSCEPTIBILITY LOCI, GROWTH-FACTOR, MOUSE MODEL, ASSOCIATION, PROTEIN, METAANALYSIS, BINDING, GENE, APOE |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10025982 |
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