The associative brain at work: Evidence from paired associative stimulation studies in humans.

Advanced search
Browse by:

Department | Year

UCL Theses | Latest

Deposit your research

The associative brain at work: Evidence from paired associative stimulation studies in humans.

Suppa, A; Quartarone, A; Siebner, H; Chen, R; Di Lazzaro, V; Del Giudice, P; Paulus, W; ... Classen, J; + view all (2017) The associative brain at work: Evidence from paired associative stimulation studies in humans. Clin Neurophysiol , 128 (11) pp. 2140-2164. 10.1016/j.clinph.2017.08.003. Green open access

[thumbnail of Rothwell_The Associative Brain at Work 4 2 2017a.pdf]

Preview

Text
Rothwell_The Associative Brain at Work 4 2 2017a.pdf - Accepted Version
Download (596kB) | Preview

Abstract

The original protocol of Paired Associative Stimulation (PAS) in humans implies repetitive cortical and peripheral nerve stimuli, delivered at specific inter-stimulus intervals, able to elicit non-invasively long-term potentiation (LTP)- and long-term depression (LTD)-like plasticity in the human motor cortex. PAS has been designed to drive cortical LTP/LTD according to the Hebbian rule of associative plasticity. Over the last two decades, a growing number of researchers have increasingly used the PAS technique to assess cortical associative plasticity in healthy humans and in patients with movement disorders and other neuropsychiatric diseases. The present review covers the physiology, pharmacology, pathology and motor effects of PAS. Further sections of the review focus on new protocols of "modified PAS" and possible future application of PAS in neuromorphic circuits designed for brain-computer interface.

Type:	Article
Title:	The associative brain at work: Evidence from paired associative stimulation studies in humans.
Location:	Netherlands
Open access status:	An open access version is available from UCL Discovery
DOI:	10.1016/j.clinph.2017.08.003
Publisher version:	https://doi.org/10.1016/j.clinph.2017.08.003
Language:	English
Additional information:	This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords:	Paired associative stimulation, Plasticity, Primary motor cortex, STDP
UCL classification:	UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences
URI:	https://discovery.ucl.ac.uk/id/eprint/10024534