Gilbert, R;
Al-Janabi, A;
Tomkins-Netzer, O;
Lightman, S;
(2017)
Statins as anti-inflammatory agents: A potential therapeutic role in sight-threatening non-infectious uveitis.
Porto Biomedical Journal
, 2
(2)
pp. 33-39.
10.1016/j.pbj.2017.01.006.
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Abstract
In addition to the known lipid-lowering effects, statins are now widely accepted to have antiinflammatory and immunomodulatory effects. Adjunctive use of statins has proven beneficial in the context of a wide range of inflammatory diseases, including rheumatoid arthritis. Evidence also suggests that statins may also have utility in the management of uveitis, a form of sight threatening inflammation which occurs in the eye. In this article, we outline our rationale behind a clinical trial of simvastatin as a steroid-sparing agent in uveitis, to which patient recruitment started last year. Potential risks associated with the clinical use of statins, including putative effects on the eyes, are discussed.
| Type: | Article |
|---|---|
| Title: | Statins as anti-inflammatory agents: A potential therapeutic role in sight-threatening non-infectious uveitis |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.pbj.2017.01.006 |
| Publisher version: | http://doi.org/10.1016/j.pbj.2017.01.006 |
| Language: | English |
| Additional information: | Copyright © 2017 PBJ-Associac¸ ao˜ Porto Biomedical/Porto Biomedical Society. Published by Elsevier Espana, ˜ S.L.U. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| Keywords: | Uveitis, Statins, Ocular inflammatory disease, Steroid-sparing agents, Anti-inflammatory |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10022861 |
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