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Number of items: 12.
Article
Bayle, ED;
Svensson, F;
Atkinson, BN;
Steadman, D;
Willis, NJ;
Woodward, HL;
Whiting, P;
... Fish, PV; + view all
(2021)
Carboxylesterase Notum Is a Druggable Target to Modulate Wnt Signaling.
Journal of Medicinal Chemistry
, 64
(8)
pp. 4289-4311.
10.1021/acs.jmedchem.0c01974.
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Chatzopoulou, M;
Martínez, RF;
Willis, NJ;
Claridge, TDW;
Wilson, FX;
Wynne, GM;
Davies, SG;
(2018)
The Dimroth rearrangement as a probable cause for structural misassignments in imidazo[1,2-a]pyrimidines: A 15N-labelling study and an easy method for the determination of regiochemistry.
Tetrahedron
, 74
(38)
pp. 5280-5288.
10.1016/j.tet.2018.06.033.
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Flanagan, DJ;
Pentinmikko, N;
Luopajärvi, K;
Willis, NJ;
Gilroy, K;
Raven, AP;
Mcgarry, L;
... Sansom, OJ; + view all
(2021)
NOTUM from Apc-mutant cells biases clonal competition to initiate cancer.
Nature
, 594
pp. 430-435.
10.1038/s41586-021-03525-z.
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Llorente-Garcia, I;
Lenn, T;
Erhardt, H;
Harriman, OL;
Liu, L-N;
Robson, A;
Chiu, S-W;
... Leake, MC; + view all
(2014)
Single-molecule in vivo imaging of bacterial respiratory complexes indicates delocalized oxidative phosphorylation.
Biochimica et Biophysica Acta (BBA) - Bioenergetics
, 1837
(6)
pp. 811-824.
10.1016/j.bbabio.2014.01.020.
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Mahy, W;
Patel, M;
Steadman, D;
Woodward, HL;
Atkinson, BN;
Svensson, F;
Willis, NJ;
... Fish, PV; + view all
(2020)
Screening of a Custom-Designed Acid Fragment Library Identifies 1-Phenylpyrroles and 1-Phenylpyrrolidines as Inhibitors of Notum Carboxylesterase Activity.
Journal of Medicinal Chemistry
, 63
(17)
pp. 9464-9483.
10.1021/acs.jmedchem.0c00660.
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Mahy, W;
Willis, NJ;
Zhao, Y;
Woodward, HL;
Svensson, F;
Sipthorp, J;
Vecchia, L;
... Fish, PV; + view all
(2020)
5-Phenyl-1,3,4-oxadiazol-2(3H)-ones Are Potent Inhibitors of Notum Carboxylesterase Activity Identified by the Optimization of a Crystallographic Fragment Screening Hit.
Journal of Medicinal Chemistry
, 63
(21)
pp. 12942-12956.
10.1021/acs.jmedchem.0c01391.
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Partridge, FA;
Bataille, CJR;
Forman, R;
Marriott, AE;
Forde-Thomas, J;
Häberli, C;
Dinsdale, RL;
... Sattelle, DB; + view all
(2021)
Structural Requirements for Dihydrobenzoxazepinone Anthelmintics: Actions against Medically Important and Model Parasites: Trichuris muris, Brugia malayi, Heligmosomoides polygyrus, and Schistosoma mansoni.
ACS Infectious Diseases
10.1021/acsinfecdis.1c00025.
(In press).
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Partridge, FA;
Brown, AE;
Buckingham, SD;
Willis, NJ;
Wynne, GM;
Forman, R;
Else, KJ;
... Sattelle, DB; + view all
(2018)
An automated high-throughput system for phenotypic screening of chemical libraries on C. elegans and parasitic nematodes.
International Journal for Parasitology: Drugs and Drug Resistance
, 8
(1)
pp. 8-21.
10.1016/j.ijpddr.2017.11.004.
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Partridge, FA;
Forman, R;
Willis, NJ;
Bataille, C;
Murphy, E;
Brown, AE;
Heyer-Chauhan, N;
... Sattelle, DB; + view all
(2018)
2,4-Diaminothieno[3,2-d]pyrimidines, a new class of anthelmintic with activity against adult and egg stages of whipworm.
PLoS Neglected Tropical Diseases
, 12
(7)
, Article e0006487. 10.1371/journal.pntd.0006487.
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Partridge, FA;
Sattelle, DB;
Heyer-Chauhan, N;
(2017)
Dihydrobenz[e][1,4]oxazepin-2(3H)-ones, a new anthelmintic chemotype immobilising whipworm and reducing infectivity in vivo.
PLOS Neglected Tropical Diseases
, 11
(2)
, Article e0005359.. 10.1371/ journal.pntd.0005359.
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Steadman, D;
Atkinson, BN;
Zhao, Y;
Willis, NJ;
Frew, S;
Monaghan, A;
Patel, C;
... Svensson, F; + view all
(2021)
Virtual Screening Directly Identifies New Fragment-Sized Inhibitors of Carboxylesterase Notum with Nanomolar Activity.
Journal of Medicinal Chemistry
, 65
(1)
pp. 562-578.
10.1021/acs.jmedchem.1c01735.
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Willis, NJ;
Bayle, ED;
Papageorgiou, G;
Steadman, D;
Atkinson, BN;
Mahy, W;
Fish, PV;
(2019)
An improved, scalable synthesis of Notum inhibitor LP-922056 using 1-chloro-1,2-benziodoxol-3-one as a superior electrophilic chlorinating agent.
Beilstein Journal of Organic Chemistry
, 15
pp. 2790-2797.
10.3762/bjoc.15.271.
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