Browse by UCL people
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Number of items: 43.
Article
Abbas, Sujath;
Pich, Oriol;
Devonshire, Ginny;
Zamani, Shahriar A;
Katz-Summercorn, Annalise;
Killcoyne, Sarah;
Cheah, Calvin;
... Secrier, Maria; + view all
(2023)
Mutational signature dynamics shaping the evolution of oesophageal adenocarcinoma.
Nature Communications
, 14
(1)
, Article 4239. 10.1038/s41467-023-39957-6.
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Albert, MC;
Uranga-Murillo, I;
Arias, M;
De Miguel, D;
Peña, N;
Montinaro, A;
Varanda, AB;
... Walczak, H; + view all
(2024)
Identification of FasL as a crucial host factor driving COVID-19 pathology and lethality.
Cell Death & Differentiation
10.1038/s41418-024-01278-6.
(In press).
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Bornschein, J;
Wernisch, L;
Secrier, M;
Miremadi, A;
Perner, J;
MacRae, S;
O'Donovan, M;
... Fitzgerald, RC; + view all
(2019)
Transcriptomic profiling reveals three molecular phenotypes of adenocarcinoma at the gastro-esophageal junction.
International Journal of Cancer
, 145
(12)
pp. 3389-3401.
10.1002/ijc.32384.
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Brown, Anna-Leigh;
Wilkins, Oscar G;
Keuss, Matthew J;
Hill, Sarah E;
Zanovello, Matteo;
Lee, Weaverly Colleen;
Bampton, Alexander;
... Fratta, Pietro; + view all
(2022)
TDP-43 loss and ALS-risk SNPs drive mis-splicing and depletion of UNC13A.
Nature
, 603
pp. 131-137.
10.1038/s41586-022-04436-3.
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Bryce-Smith, Sam;
Brown, Anna-Leigh;
Chien, Max ZYJ;
Dattilo, Dario;
Mehta, Puja R;
Mattedi, Francesca;
Barattucci, Simone;
... Fratta, Pietro; + view all
(2025)
TDP-43 loss induces cryptic polyadenylation in ALS/FTD.
Nature Neuroscience
10.1038/s41593-025-02050-w.
(In press).
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Cappelli, Sara;
Spalloni, Alida;
Feiguin, Fabian;
Visani, Giulia;
Šušnjar, Urša;
Brown, Anna-Leigh;
NYGC ALS, Consortium;
... Buratti, Emanuele; + view all
(2022)
NOS1AP is a novel molecular target and critical factor in TDP-43 pathology.
Brain Communications
, 4
(5)
, Article fcac242. 10.1093/braincomms/fcac242.
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Contino, G;
Eldridge, MD;
Secrier, M;
Bower, L;
Fels Elliott, R;
Weaver, J;
Lynch, AG;
... Fitzgerald, RC; + view all
(2016)
Whole-genome sequencing of nine esophageal adenocarcinoma cell lines.
F1000Research
, 5
, Article 1336. 10.12688/f1000research.7033.1.
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Cutty, SJ;
Hughes, FA;
Ortega-Prieto, P;
Desai, S;
Thomas, P;
Fets, LV;
Secrier, M;
(2024)
Pro-survival roles for p21(Cip1/Waf1) in non-small cell lung cancer.
British Journal of Cancer
10.1038/s41416-024-02928-9.
(In press).
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Frankell, AM;
Jammula, S;
Li, X;
Contino, G;
Killcoyne, S;
Abbas, S;
Perner, J;
... Fitzgerald, RC; + view all
(2019)
The landscape of selection in 551 esophageal adenocarcinomas defines genomic biomarkers for the clinic.
Nature Genetics
, 51
pp. 506-516.
10.1038/s41588-018-0331-5.
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Ganguli, P;
Basanta, CC;
Acha-Sagredo, A;
Misetic, H;
Armero, M;
Mendez, A;
Zahra, A;
... Ciccarelli, FD; + view all
(2025)
Context-dependent effects of CDKN2A and other 9p21 gene losses during the evolution of esophageal cancer.
Nature Cancer
10.1038/s43018-024-00876-0.
(In press).
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Garcia, E;
Hayden, A;
Birts, C;
Britton, E;
Cowie, A;
Pickard, K;
Mellone, M;
... Tavare, S; + view all
(2016)
Authentication and characterisation of a new oesophageal adenocarcinoma cell line: MFD-1.
Scientific Reports
, 6
(1)
, Article 32417. 10.1038/srep32417.
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Garcia, E;
Hayden, A;
Birts, C;
Britton, E;
Rogerson, C;
Bleaney, CW;
Cowie, A;
... Tavare, S; + view all
(2019)
Authentication and characterisation of a new oesophageal adenocarcinoma cell line: MFD-1 (vol 6, 32417, 2016).
Scientific Reports
, 9
, Article 318. 10.1038/s41598-018-37591-7.
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Izadi, F;
Sharpe, BP;
Breininger, SP;
Secrier, M;
Gibson, J;
Walker, RC;
Rahman, S;
... On Behalf Of Occams; + view all
(2021)
Genomic Analysis of Response to Neoadjuvant Chemotherapy in Esophageal Adenocarcinoma.
Cancers
, 13
(14)
, Article 3394. 10.3390/cancers13143394.
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Jacobson, Daniel H;
Pan, Shi;
Fisher, Jasmin;
Secrier, Maria;
(2023)
Multi-scale characterisation of homologous recombination deficiency in breast cancer.
Genome Medicine
, 15
, Article 90. 10.1186/s13073-023-01239-7.
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Jammula, S;
Katz-Summercorn, AC;
Li, X;
Linossi, C;
Smyth, E;
Killcoyne, S;
Biasci, D;
... Fitzgerald, RC; + view all
(2020)
Identification of Subtypes of Barrett’s Esophagus and Esophageal Adenocarcinoma Based on DNA Methylation Profiles and Integration of Transcriptome and Genome Data.
Gastroenterology
, 158
(6)
1682-1697.e1.
10.1053/j.gastro.2020.01.044.
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Jarvis, S;
Birsa, N;
Secrier, M;
Fratta, P;
Plagnol, V;
(2020)
A Comparison of Low Read Depth QuantSeq 3 ' Sequencing to Total RNA-Seq in FUS Mutant Mice.
Frontiers in Genetics
, 11
, Article 562445. 10.3389/fgene.2020.562445.
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Kazachenka, A;
Loong, JH;
Attig, J;
Young, GR;
Ganguli, P;
Devonshire, G;
Grehan, N;
... Bartlett, F; + view all
(2023)
The transcriptional landscape of endogenous retroelements delineates esophageal adenocarcinoma subtypes.
NAR Cancer
, 5
(3)
, Article zcad040. 10.1093/narcan/zcad040.
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Knight, WRC;
McEwen, R;
Byrne, BE;
Habib, W;
Bott, R;
Zylstra, J;
Mahadeva, U;
... Fickling, W; + view all
(2020)
Endoscopic tumour morphology impacts survival in adenocarcinoma of the oesophagus.
European Journal of Surgical Oncology
, 46
(12)
pp. 2257-2261.
10.1016/j.ejso.2020.07.003.
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Li, X;
Francies, HE;
Secrier, M;
Perner, J;
Miremadi, A;
Galeano-Dalmau, N;
Barendt, WJ;
... Garnett, MJ; + view all
(2018)
Organoid cultures recapitulate esophageal adenocarcinoma heterogeneity providing a model for clonality studies and precision therapeutics.
Nature Communications
, 9
, Article 2983. 10.1038/s41467-018-05190-9.
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Malagoli Tagliazucchi, Guidantonio;
Wiecek, Anna J;
Withnell, Eloise;
Secrier, Maria;
(2023)
Genomic and microenvironmental heterogeneity shaping epithelial-to-mesenchymal trajectories in cancer.
Nature Communications
, 14
, Article 789. 10.1038/s41467-023-36439-7.
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Mejia Maza, A;
Jarvis, S;
Lee, WC;
Cunningham, TJ;
Schiavo, G;
Secrier, M;
Fratta, P;
... Sudre, CH; + view all
(2021)
NMJ-Analyser identifies subtle early changes in mouse models of neuromuscular disease.
Scientific Reports
, 11
(1)
, Article 12251. 10.1038/s41598-021-91094-6.
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Mourikis, TP;
Benedetti, L;
Foxall, E;
Temelkovski, D;
Nulsen, J;
Perner, J;
Cereda, M;
... Ciccarelli, FD; + view all
(2019)
Patient-specific cancer genes contribute to recurrently perturbed pathways and establish therapeutic vulnerabilities in esophageal adenocarcinoma.
Nature Communications
, 10
(1)
, Article 3101. 10.1038/s41467-019-10898-3.
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Ng, AWT;
Contino, G;
Killcoyne, S;
Devonshire, G;
Hsu, R;
Abbas, S;
Su, J;
... Fitzgerald, RC; + view all
(2022)
Rearrangement processes and structural variations show evidence of selection in oesophageal adenocarcinomas.
Communications Biology
, 5
(1)
, Article 335. 10.1038/s42003-022-03238-7.
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Noble, F;
Lloyd, MA;
Turkington, R;
Griffiths, E;
O'Donovan, M;
O'Neill, JR;
Mercer, S;
... Tavaré, S; + view all
(2017)
Multicentre cohort study to define and validate pathological assessment of response to neoadjuvant therapy in oesophagogastric adenocarcinoma.
British Journal of Surgery
, 104
(13)
pp. 1816-1828.
10.1002/bjs.10627.
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Noorani, A;
Bornschein, J;
Lynch, AG;
Secrier, M;
Achilleos, A;
Eldridge, M;
Bower, L;
... Fitzgerald, RC; + view all
(2017)
A comparative analysis of whole genome sequencing of esophageal adenocarcinoma pre- and post-chemotherapy (vol 27, pg 902, 2017).
Genome Research
, 27
(10)
p. 1782.
10.1101/gr.229153.117.
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Noorani, A;
Bornschein, J;
Lynch, AG;
Secrier, M;
Achilleos, A;
Eldridge, M;
Bower, L;
... OCCAMS Consortium, .; + view all
(2017)
A comparative analysis of whole genome sequencing of esophageal adenocarcinoma pre- and post-chemotherapy.
Genome Research
, 27
(6)
pp. 902-912.
10.1101/gr.214296.116.
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Noorani, A;
Li, X;
Goddard, M;
Crawte, J;
Alexandrov, LB;
Secrier, M;
Eldridge, MD;
... Fitzgerald, RC; + view all
(2020)
Genomic evidence supports a clonal diaspora model for metastases of esophageal adenocarcinoma.
Nature Genetics
, 52
, Article 74. 10.1038/s41588-019-0551-3.
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Ococks, E;
Sharma, S;
Tian Ng, AW;
Aleshin, A;
Fitzgerald, RC;
Smyth, E;
OCCAMS Consortium, .;
... Petty, RD; + view all
(2021)
Serial ctDNA detection using a personalized, tumor-informed assay in esophageal adenocarcinoma patients following resection.
Gastroenterology
, 161
(5)
1705-1708.e2.
10.1053/j.gastro.2021.07.011.
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Pan, S;
Secrier, M;
(2023)
HistoMIL: A Python package for training multiple instance learning models on histopathology slides.
iScience
, 26
(10)
, Article 108073. 10.1016/j.isci.2023.108073.
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Peters, CJ;
Ang, Y;
Ciccarelli, FD;
Coles, H;
Coleman, HG;
Contino, G;
Crosby, T;
... Fitzgerald, RC; + view all
(2024)
A decade of the Oesophageal Cancer Clinical and Molecular Stratification Consortium.
Nature Medicine
, 30
pp. 14-16.
10.1038/s41591-023-02676-y.
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Prudencio, M;
Humphrey, J;
Pickles, S;
Brown, A-L;
Hill, SE;
Kachergus, J;
Shi, J;
... Petrucelli, L; + view all
(2020)
Truncated stathmin-2 is a marker of TDP-43 pathology in frontotemporal dementia.
Journal of Clinical Investigation
10.1172/JCI139741.
(In press).
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Rokan, Ahmed;
Diniz, Mariana O;
De Las Heras, Jose I;
Hall, Callum;
Noorsaeed, Somaya;
Bennett, Clare L;
Secrier, Maria;
... Fassati, Ariberto; + view all
(2025)
Evolution of a melanoma that escapes allogeneic rejection.
Cell Reports
, 44
(9)
, Article 116288. 10.1016/j.celrep.2025.116288.
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Sawas, T;
Killcoyne, S;
Iyer, PG;
Wang, KK;
Smyrk, TC;
Kisiel, JB;
Qin, Y;
... OCCAMS Consortium; + view all
(2018)
Identification of Prognostic Phenotypes of Esophageal Adenocarcinoma in 2 Independent Cohorts.
Gastroenterology
, 155
(6)
pp. 1720-1728.
10.1053/j.gastro.2018.08.036.
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Secrier, Maria;
McGrath, Lara;
Ng, Felicia;
Gulati, Sakshi;
Raymond, Amelia;
Nuttall, Barrett RB;
Berthe, Julie;
... Angell, Helen K; + view all
(2023)
Immune Cell Abundance and T-cell Receptor Landscapes Suggest New Patient Stratification Strategies in Head and Neck Squamous Cell Carcinoma.
Cancer Research Communications
, 3
(10)
pp. 2133-2145.
10.1158/2767-9764.CRC-23-0155.
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Secrier, M;
Li, X;
De Silva, N;
Eldridge, MD;
Contino, G;
Bornschein, J;
Macrae, S;
... Garnett, MJ; + view all
(2016)
Mutational signatures in esophageal adenocarcinoma define etiologically distinct subgroups with therapeutic relevance.
Nature Genetics
, 48
(10)
pp. 1131-1141.
10.1038/ng.3659.
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Seddighi, Sahba;
Qi, Yue A;
Brown, Anna-Leigh;
Wilkins, Oscar G;
Bereda, Colleen;
Belair, Cedric;
Zhang, Yong-Jie;
... Ward, Michael E; + view all
(2024)
Mis-spliced transcripts generate de novo proteins in TDP-43–related ALS/FTD.
Science Translational Medicine
, 16
(734)
10.1126/scitranslmed.adg7162.
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Šušnjar, Urša;
Škrabar, Neva;
Brown, Anna-Leigh;
Abbassi, Yasmine;
Phatnani, Hemali;
NYGC ALS Consortium, .;
Cortese, Andrea;
... Buratti, Emanuele; + view all
(2022)
Cell environment shapes TDP-43 function with implications in neuronal and muscle disease.
Communications Biology
, 5
, Article 314. 10.1038/s42003-022-03253-8.
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Talukdar, FR;
di Pietro, M;
Secrier, M;
Moehler, M;
Goepfert, K;
Lima, SSC;
Pinto, LFR;
... Herceg, Z; + view all
(2018)
Molecular landscape of esophageal cancer: implications for early detection and personalized therapy.
Annals of the New York Academy of Sciences
, 1434
(1)
pp. 342-359.
10.1111/nyas.13876.
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Turkington, RC;
Knight, LA;
Blayney, JK;
Secrier, M;
Douglas, R;
Parkes, EE;
Sutton, EK;
... Oesophageal Cancer Clinical and Molecular Stratification (OCCAMS, .; + view all
(2019)
Immune activation by DNA damage predicts response to chemotherapy and survival in oesophageal adenocarcinoma.
Gut
10.1136/gutjnl-2018-317624.
(In press).
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Wellman, Rachel;
Jacobson, Daniel;
Secrier, Maria;
Labbadia, John;
(2024)
Distinct patterns of proteostasis network gene expression are associated with different prognoses in melanoma patients.
Scientific Reports
, 14
, Article 198. 10.1038/s41598-023-50640-0.
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Wiecek, Anna J;
Cutty, Stephen J;
Kornai, Daniel;
Parreno-Centeno, Mario;
Gourmet, Lucie E;
Tagliazucchi, Guidantonio Malagoli;
Jacobson, Daniel H;
... Secrier, Maria; + view all
(2023)
Genomic hallmarks and therapeutic implications of G0 cell cycle arrest in cancer.
Genome Biology
, 24
(1)
, Article 128. 10.1186/s13059-023-02963-4.
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Wiecek, AJ;
Jacobson, DH;
Lason, W;
Secrier, M;
(2021)
Pan-Cancer Survey of Tumor Mass Dormancy and Underlying Mutational Processes.
Frontiers in Cell and Developmental Biology
, 9
, Article 698659. 10.3389/fcell.2021.698659.
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Proceedings paper
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Pan, Shi;
Chen, Jianan;
Secrier, Maria;
(2026)
Teaching Pathology Foundation Models to Accurately Predict Gene Expression with Parameter Efficient Knowledge Transfer.
In: Gee, James C and Alexander, Daniel C and Hong, Jaesung and Iglesias, Juan Eugenio and Sudre, Carole H and Venkataraman, Archana and Golland, Polina and Kim, Jong Hyo and Park, Jinah, (eds.)
Medical Image Computing and Computer Assisted Intervention – MICCAI 2025.
(pp. pp. 605-613).
Springer: Cham, Switzerland.
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