Browse by UCL people
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Number of items: 18.
Article
Abar, Leila;
Zuber, Verena;
Otto, Georg W;
Tzoulaki, Ioanna;
Dehghan, Abbas;
(2024)
Unravelling genetic architecture of circulatory amino acid levels, and their effect on risk of complex disorders.
NAR Genomics and Bioinformatics
, 6
(2)
, Article lqae046. 10.1093/nargab/lqae046.
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Apps, John R;
Gonzalez-Meljem, Jose Mario;
Guiho, Romain;
Pickles, Jessica C;
Prince, Eric;
Schwalbe, Edward;
Joshi, Nikhil;
... Martinez-Barbera, Juan Pedro; + view all
(2024)
Recurrent adamantinomatous craniopharyngiomas show MAPK pathway activation, clonal evolution and rare TP53-loss-mediated malignant progression.
Acta Neuropathologica Communications
, 12
, Article 127. 10.1186/s40478-024-01838-4.
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Brial, F;
Le Lay, A;
Hedjazi, L;
Tsang, T;
Fearnside, JF;
Otto, GW;
Alzaid, F;
... Gauguier, D; + view all
(2019)
Systems Genetics of Hepatic Metabolome Reveals Octopamine as a Target for Non-Alcoholic Fatty Liver Disease Treatment.
Scientific Reports
, 9
, Article 3656. 10.1038/s41598-019-40153-0.
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Chagraoui, H;
Kristiansen, MS;
Ruiz, JP;
Serra-Barros, A;
Richter, J;
Hall-Ponselé, E;
Gray, N;
... Porcher, C; + view all
(2018)
SCL/TAL1 cooperates with Polycomb RYBP-PRC1 to suppress alternative lineages in blood-fated cells.
Nature Communications
, 9
, Article 5375. 10.1038/s41467-018-07787-6.
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Dumas, M-E;
Domange, C;
Calderari, S;
Martínez, AR;
Ayala, R;
Wilder, SP;
Suárez-Zamorano, N;
... Gauguier, D; + view all
(2016)
Topological analysis of metabolic networks integrating co-segregating transcriptomes and metabolomes in type 2 diabetic rat congenic series.
Genome Medicine
, 8
, Article 101. 10.1186/s13073-016-0352-6.
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Fazal, SV;
Gomez-Sanchez, JA;
Wagstaff, LJ;
Musner, N;
Otto, G;
Janz, M;
Mirsky, R;
(2017)
Graded elevation of c-Jun in Schwann cells in vivo: gene dosage determines effects on development, re-myelination, tumorigenesis and hypomyelination.
Journal of Neuroscience
, 37
(50)
pp. 12297-12313.
10.1523/JNEUROSCI.0986-17.2017.
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Freke, Grace Mercedes;
Martins, Tiago;
Davies, Rosalind Jane;
Beyer, Tina;
Seda, Marian;
Peskett, Emma;
Haq, Naila;
... Jenkins, Dagan; + view all
(2023)
De-Suppression of Mesenchymal Cell Identities and Variable Phenotypic Outcomes Associated with Knockout of Bbs1.
Cells
, 12
(22)
, Article 2662. 10.3390/cells12222662.
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Fuentes-Fayos, AC;
G-García, ME;
Sánchez-Medianero, T;
Apps, J;
Flores-Martínez, Á;
De la Rosa-Herencia, AS;
Gil-Duque, I;
... Luque, RM; + view all
(2025)
Impaired splicing machinery in craniopharyngiomas unveils PRPF8 and RAVER1 as novel biomarkers and therapeutic targets.
Acta Neuropathologica Communications
, 13
(1)
p. 142.
10.1186/s40478-025-02040-w.
(In press).
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Gregory, Louise C;
Cionna, Cecilia;
Cerbone, Manuela;
GOSgene;
Dattani, Mehul T;
(2023)
Identification of genetic variants and phenotypic characterization of a large cohort of patients with congenital hypopituitarism and related disorders.
Genetics in Medicine
, 25
(9)
, Article 100881. 10.1016/j.gim.2023.100881.
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Juban, G;
Sakakini, N;
Chagraoui, H;
Cruz Hernandez, D;
Cheng, Q;
Soady, K;
Stoilova, B;
... Vyas, P; + view all
(2020)
Oncogenic Gata1 Causes Stage-Specific Megakaryocyte Differentiation Delay.
Haematologica
10.3324/haematol.2019.244541.
(In press).
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Kaisaki, PJ;
Otto, GW;
Argoud, K;
Collins, SC;
Wallis, RH;
Wilder, SP;
Yau, AC;
... Gauguier, D; + view all
(2016)
Transcriptome Profiling in Rat Inbred Strains and Experimental Cross Reveals Discrepant Genetic Architecture of Genome-Wide Gene Expression.
G3: Genes, Genomes, Genetics
10.1534/g3.116.033274.
(In press).
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Karamitros, D;
Stoilova, B;
Aboukhalil, Z;
Hamey, F;
Reinisch, A;
Samitsch, M;
Quek, L;
... Vyas, P; + view all
(2018)
Single-cell analysis reveals the continuum of human lympho-myeloid progenitor cells.
Nature Immunologyvolume
, 19
pp. 85-97.
10.1038/s41590-017-0001-2.
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Otto, GW;
Kaisaki, PJ;
Brial, F;
Le Lay, A;
Cazier, J-B;
Mott, R;
Gauguier, D;
(2019)
Conserved properties of genetic architecture of renal and fat transcriptomes in rat models of insulin resistance.
Disease Models & Mechanisms
, 12
(7)
10.1242/dmm.038539.
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Piper, CJM;
Wilkinson, MGL;
Deakin, CT;
Otto, GW;
Dowle, S;
Duurland, CL;
Adams, S;
... Marques, R; + view all
(2018)
CD19+CD24hiCD38hi B Cells Are Expanded in Juvenile Dermatomyositis and Exhibit a Pro-Inflammatory Phenotype After Activation Through Toll-Like Receptor 7 and Interferon-α.
Frontiers in Immunology
, 9
, Article 1372. 10.3389/fimmu.2018.01372.
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Quek, L;
Otto, GW;
Garnett, C;
Lhermitte, L;
Karamitros, D;
Stoilova, B;
Lau, I-J;
... Vyas, P; + view all
(2016)
Genetically distinct leukemic stem cells in human CD34(-) acute myeloid leukemia are arrested at a hemopoietic precursor-like stage.
Journal of Experimental Medicine
, 213
(8)
pp. 1513-1535.
10.1084/jem.20151775.
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Shimizu, H;
Langenbacher, AD;
Huang, J;
Wang, K;
Otto, G;
Geisler, R;
Wang, Y;
(2017)
The Calcineurin-FoxO-MuRF1 signaling pathway regulates myofibril integrity in cardiomyocytes.
eLife
, 6
, Article e27955. 10.7554/eLife.27955.
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Wagstaff, LJ;
Gomez-Sanchez, JA;
Fazal, SV;
Otto, GW;
Kilpatrick, AM;
Michael, K;
Wong, LY;
... Jessen, KR; + view all
(2021)
Failures of nerve regeneration caused by aging or chronic denervation are rescued by restoring Schwann cell c-Jun.
eLife
, 10
, Article e62232. 10.7554/eLife.62232.
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Wilkinson, Meredyth G Ll;
Moulding, Dale;
McDonnell, Thomas CR;
Orford, Michael;
Wincup, Chris;
Ting, Joanna YJ;
Otto, Georg W;
... Wedderburn, Lucy R; + view all
(2022)
Role of CD14+ monocyte-derived oxidised mitochondrial DNA in the inflammatory interferon type 1 signature in juvenile dermatomyositis.
Annals of the Rheumatic Diseases
10.1136/ard-2022-223469.
(In press).
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