Browse by UCL people
Group by: Type | Date
Number of items: 17.
Article
Aldous, Sarah G;
Smith, Edward J;
Landles, Christian;
Osborne, Georgina F;
Cañibano-Pico, Maria;
Nita, Iulia M;
Phillips, Jemima;
... Bates, Gillian P; + view all
(2024)
A CAG repeat threshold for therapeutics targeting somatic instability in Huntington's disease.
Brain
, 147
(5)
pp. 1784-1798.
10.1093/brain/awae063.
|
|
Bjorkqvist, M;
Wild, EJ;
Thiele, J;
Silvestroni, A;
Andre, R;
Lahiri, N;
Raibon, E;
... Tabrizi, SJ; + view all
(2008)
A novel pathogenic pathway of immune activation detectable before clinical onset in Huntington's disease.
Journal of Experimental Medicine
, 205
(8)
1869 - 1877.
10.1084/jem.20080178.
|
 |
|
Bryant, DT;
Landles, C;
Papadopoulou, AS;
Benjamin, AC;
Duckworth, JK;
Rosahl, T;
Benn, CL;
(2017)
Disruption to schizophrenia-associated gene Fez1 in the hippocampus of HDAC11 knockout mice.
Scientific Reports
, 7
(1)
, Article 11900. 10.1038/s41598-017-11630-1.
|
 |
|
Fienko, Sandra;
Landles, Christian;
Sathasivam, Kirupa;
McAteer, Sean J;
Milton, Rebecca E;
Osborne, Georgina F;
Smith, Edward J;
... Bates, Gillian P; + view all
(2022)
Alternative processing of human HTT mRNA with implications for Huntington's disease therapeutics.
Brain
10.1093/brain/awac241.
(In press).
|
|
Franich, NR;
Hickey, MA;
Zhu, C;
Osborne, GF;
Ali, N;
Chu, T;
Bove, NH;
... Chesselet, M-F; + view all
Phenotype onset in Huntington's disease knock-in mice is correlated with the incomplete splicing of the mutant huntingtin gene.
Journal of Neuroscience Research
10.1002/jnr.24493.
(In press).
|
|
|
Hegde, RN;
Chiki, A;
Petricca, L;
Martufi, P;
Arbez, N;
Mouchiroud, L;
Auwerx, J;
... Lashuel, HA; + view all
(2020)
TBK1 phosphorylates mutant Huntingtin and suppresses its aggregation and toxicity in Huntington's disease models.
The EMBO Journal
, Article e104671. 10.15252/embj.2020104671.
(In press).
|
|
|
Landles, Christian;
Osborne, Georgina F;
Phillips, Jemima;
Canibano-Pico, Maria;
Nita, Iulia M;
Ali, Nadira;
Bobkov, Konstantin;
... Bates, Gillian P; + view all
(2024)
Mutant huntingtin protein decreases with CAG repeat expansion: implications for therapeutics and bioassays.
Brain Communications
, 6
(6)
, Article ARTN fcae410. 10.1093/braincomms/fcae410.
|
|
|
Landles, C;
Milton, RE;
Ali, N;
Flomen, R;
Flower, M;
Schindler, F;
Gomez-Paredes, C;
... Bates, GP; + view all
(2020)
Subcellular Localization And Formation Of Huntingtin Aggregates Correlates With Symptom Onset And Progression In A Huntington’S Disease Model.
Brain Communications
, 2
(2)
, Article fcaa066. 10.1093/braincomms/fcaa066.
|
|
|
Landles, C;
Milton, RE;
Jean, A;
McLarnon, S;
McAteer, SJ;
Taxy, BA;
Osborne, GF;
... Bates, GP; + view all
(2021)
Development of novel bioassays to detect soluble and aggregated Huntingtin proteins on three technology platforms.
Brain Communications
, 3
(1)
, Article fcaa231. 10.1093/braincomms/fcaa231.
|
|
|
Neueder, A;
Landles, C;
Ghosh, R;
Howland, D;
Myers, RH;
Faull, RLM;
Tabrizi, SJ;
(2017)
The pathogenic exon 1 HTT protein is produced by incomplete splicing in Huntington’s disease patients.
Scientific Reports
, 7
(1)
, Article 1307. 10.1038/s41598-017-01510-z.
|
|
|
Smith, Edward J;
Sathasivam, Kirupa;
Landles, Christian;
Osborne, Georgina F;
Mason, Michael A;
Gomez-Paredes, Casandra;
Taxy, Bridget A;
... Bates, Gillian P; + view all
(2023)
Early detection of exon 1 huntingtin aggregation in zQ175 brains by molecular and histological approaches.
Brain Communications
, 5
(1)
, Article fcad010. 10.1093/braincomms/fcad010.
|
|
Sogorb-Gonzalez, Marina;
Landles, Christian;
Caron, Nicholas S;
Stam, Anouk;
Osborne, Georgina;
Hayden, Michael R;
Howland, David;
... Evers, Melvin; + view all
(2024)
Exon 1-targeting miRNA reduces the pathogenic exon 1 HTT protein in Huntington's disease models.
Brain
, 147
(12)
pp. 4043-4055.
10.1093/brain/awae266.
|
|
|
Weiss, A;
Träger, U;
Wild, EJ;
Grueninger, S;
Farmer, R;
Landles, C;
Scahill, RI;
... Tabrizi, SJ; + view all
(2012)
Mutant huntingtin fragmentation in immune cells tracks Huntington's disease progression.
Journal of Clinical Investigation
, 122
(10)
3731 - 3736.
10.1172/JCI64565.
|
|
|
Zhou, Y;
Peskett, TR;
Landles, C;
Warner, JB;
Sathasivam, K;
Smith, EJ;
Chen, S;
... Saibil, HR; + view all
(2021)
Correlative light and electron microscopy suggests that mutant huntingtin dysregulates the endolysosomal pathway in presymptomatic Huntington’s disease.
Acta Neuropathologica Communications
, 9
, Article 70. 10.1186/s40478-021-01172-z.
|
|
Book chapter
|
Landles, C;
BATES, GP;
(2014)
Preclinical Experimental Therapeutics.
In: BATES, GP and Tabrizi, SJ and Jones, L, (eds.)
Huntington's Disease.
(pp. 410-461).
Oxford University Press: Oxford, UK.
|
|
Conference item
|
Zhou, Y;
Young, LJ;
Stephens, AS;
Landles, C;
Kaminski, C;
Schierle, GSK;
Bates, GP;
(2016)
B6 Super-resolution fluorescence imaging of the seeding and polymerizatoin of the huntingtin exon 1 protein.
Presented at: European Huntington's Disease Network 9th Plenary Meeting, Hague, Netherlands.
|
|
Poster
|
Landles, C;
Benjamin, A;
Lazell, H;
BATES, GP;
(2015)
Subcellular Localisation of Histone Deacetylase (HDAC) 4 and HDAC5 at the Synapse in R6/2 Mice.
Presented at: CAG Triplet Repeat Disorders, Gordon Research Conference, Lucca (Barga), Italy.
|
|
