Browse by UCL people
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Number of items: 21.
Article
Arber, C;
Alatza, A;
Leckey, CA;
Paterson, RW;
Zetterberg, H;
Wray, S;
(2021)
Mass spectrometry analysis of tau and amyloid-beta in iPSC-derived models of Alzheimer's disease and dementia.
Journal of Neurochemistry
10.1111/jnc.15315.
(In press).
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Arber, C;
Angelova, PR;
Wiethoff, S;
Tsuchiya, Y;
Mazzacuva, F;
Preza, E;
Bhatia, KP;
... Wray, S; + view all
(2017)
iPSC-derived neuronal models of PANK2-associated neurodegeneration reveal mitochondrial dysfunction contributing to early disease.
PLoS One
, 12
(9)
, Article e0184104. 10.1371/journal.pone.0184104.
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Arber, C;
Li, A;
Houlden, H;
Wray, S;
(2016)
Insights into molecular mechanisms of disease in Neurodegeneration with Brain Iron Accumulation; unifying theories.
Neuropathol Appl Neurobiol
, 42
(3)
pp. 220-241.
10.1111/nan.12242.
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Arber, C;
Lovejoy, C;
Harris, L;
Willumsen, N;
Alatza, A;
Casey, JM;
Lines, G;
... Wray, S; + view all
(2021)
Familial Alzheimer's Disease Mutations in PSEN1 Lead to Premature Human Stem Cell Neurogenesis.
Cell Reports
, 34
(2)
, Article 108615. 10.1016/j.celrep.2020.108615.
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Arber, C;
Lovejoy, C;
Wray, S;
(2017)
Stem cell models of Alzheimer's disease: progress and challenges.
Alzheimer's Research & Therapy
, 9
(1)
, Article 42. 10.1186/s13195-017-0268-4.
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Arber, C;
Toombs, J;
Lovejoy, C;
Ryan, NS;
Paterson, RW;
Willumsen, N;
Gkanatsiou, E;
... Wray, S; + view all
(2020)
Familial Alzheimer’s disease patient-derived neurons reveal distinct mutation-specific effects on amyloid beta.
Molecular Psychiatry
, 25
pp. 2919-2931.
10.1038/s41380-019-0410-8.
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Arber, C;
Villegas-Llerena, C;
Toombs, J;
Pocock, JM;
Ryan, NS;
Fox, NC;
Zetterberg, H;
... Wray, S; + view all
(2019)
Amyloid precursor protein processing in human neurons with an allelic series of the PSEN1 intron 4 deletion mutation and total presenilin-1 knockout.
Brain Communications
10.1093/braincomms/fcz024.
(In press).
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Garcia-Reitboeck, P;
Phillips, A;
Piers, TM;
Villegas-Llerena, C;
Butler, M;
Mallach, A;
Rodrigues, C;
... Pocock, JM; + view all
(2018)
Human Induced Pluripotent Stem Cell-Derived Microglia-Like Cells Harboring TREM2 Missense Mutations Show Specific Deficits in Phagocytosis.
Cell Reports
, 24
(9)
pp. 2300-2311.
10.1016/j.celrep.2018.07.094.
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Hall, CE;
Yao, Z;
Choi, M;
Tyzack, GE;
Serio, A;
Luisier, R;
Harley, J;
... Patani, R; + view all
(2017)
Progressive Motor Neuron Pathology and the Role of Astrocytes in a Human Stem Cell Model of VCP-Related ALS.
Cell Reports
, 19
(9)
pp. 1739-1749.
10.1016/j.celrep.2017.05.024.
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Lorenzi, M;
Altmann, A;
Gutman, B;
Wray, S;
Arber, C;
Hibar, D;
Jahanshad, N;
... Ourselin, S; + view all
(2018)
Susceptibility of brain atrophy to TRIB3 in Alzheimer’s disease: evidence from functional prioritization in imaging-genetics.
Proceedings of the National Academy of Sciences of the United States of America
, 115
(12)
pp. 3162-3167.
10.1073/pnas.1706100115.
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Ludtmann, MHR;
Arber, C;
Bartolome, F;
de Vicente, M;
Preza, E;
Carro, E;
Houlden, H;
... Abramov, AY; + view all
(2017)
Mutations in valosin-containing protein (VCP) decrease ADP/ATP translocation across the mitochondrial membrane and impair energy metabolism in human neurons.
Journal of Biological Chemistry
, 292
(21)
pp. 8907-8917.
10.1074/jbc.M116.762898.
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Mallach, A;
Gobom, J;
Arber, C;
Piers, TM;
Hardy, J;
Wray, S;
Zetterberg, H;
(2021)
Differential stimulation of pluripotent stem cell-derived human microglia leads to exosomal proteomic changes affecting neurons.
Cells
, 10
(11)
, Article 2866. 10.3390/cells10112866.
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Mamais, A;
Manzoni, C;
Nazish, I;
Arber, C;
Sonustun, B;
Wray, S;
Warner, T;
... Bandopadhyay, R; + view all
(2018)
Analysis of macroautophagy related proteins in G2019S LRRK2 Parkinson's disease brains with Lewy Body pathology.
Brain Research
, 1701
pp. 75-84.
10.1016/j.brainres.2018.07.023.
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Nazish, I;
Arber, C;
Piers, TM;
Warner, TT;
Hardy, JA;
Lewis, PA;
Pocock, JM;
(2021)
Abrogation of LRRK2 dependent Rab10 phosphorylation with TLR4 activation and alterations in evoked cytokine release in immune cells.
Neurochemistry International
, 147
, Article 105070. 10.1016/j.neuint.2021.105070.
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O'Connor, A;
Pannee, J;
Poole, T;
Arber, C;
Portelius, E;
Swift, IJ;
Heslegrave, AJ;
... Fox, NC; + view all
(2021)
Plasma amyloid-β ratios in autosomal dominant Alzheimer's disease: the influence of genotype.
Brain
10.1093/brain/awab166.
(In press).
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Rajani, Rikesh M;
Ellingford, Robert;
Hellmuth, Mariam;
Harris, Samuel S;
Taso, Orjona S;
Graykowski, David;
Lam, Francesca Kar Wey;
... Busche, Marc Aurel; + view all
(2024)
Selective suppression of oligodendrocyte-derived amyloid beta rescues neuronal dysfunction in Alzheimer's disease.
PLoS Biology
, 22
(7)
, Article ARTN e3002727. 10.1371/journal.pbio.3002727.
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Seto-Salvia, N;
Esteras, N;
de Silva, R;
de Pablo-Fernandez, E;
Arber, C;
Toomey, CE;
Polke, JM;
... Warner, TT; + view all
(2021)
Elevated 4R-tau in astrocytes from asymptomatic carriers of the MAPT 10+16 intronic mutation.
Journal of Cellular and Molecular Medicine
10.1111/jcmm.17136.
(In press).
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Sposito, T;
Preza, E;
Mahoney, CJ;
Setó-Salvia, N;
Ryan, NS;
Morris, HR;
Arber, C;
... Wray, S; + view all
(2015)
Developmental regulation of tau splicing is disrupted in stem cell-derived neurons from frontotemporal dementia patients with the 10 + 16 splice-site mutation in MAPT.
Human Molecular Genetics
, 24
(18)
pp. 5260-5269.
10.1093/hmg/ddv246.
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Toombs, J;
Foiani, MS;
Wellington, H;
Paterson, RW;
Arber, C;
Heslegrave, A;
Lunn, MP;
... Zetterberg, H; + view all
(2018)
Amyloid β peptides are differentially vulnerable to preanalytical surface exposure, an effect incompletely mitigated by the use of ratios.
Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
, 10
pp. 311-321.
10.1016/j.dadm.2018.02.005.
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Wiethoff, S;
Arber, C;
Li, A;
Wray, S;
Houlden, H;
Patani, R;
(2015)
Using human induced pluripotent stem cells to model cerebellar disease: Hope and hype.
Journal of Neurogenetics
, 29
(2-3)
pp. 95-102.
10.3109/01677063.2015.1053478.
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Willumsen, Nanet;
Arber, Charles;
Lovejoy, Christopher;
Toombs, Jamie;
Alatza, Argyro;
Weston, Philip SJ;
Chávez-Gutiérrez, Lucia;
... Wray, Selina; + view all
(2023)
The PSEN1 E280G mutation leads to increased amyloid-β43 production in induced pluripotent stem cell neurons and deposition in brain tissue.
Brain Communications
, 5
(1)
, Article fcac321. 10.1093/braincomms/fcac321.
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