Browse by UCL people
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Number of items: 14.
Article
Fox, Thomas Andrew;
Houghton, Benjamin Christopher;
Petersone, Lina;
Waters, Erin;
Edner, Natalie Mona;
McKenna, Alex;
Preham, Olivier;
... Morris, Emma Catherine; + view all
(2022)
Therapeutic gene editing of T cells to correct CTLA-4 insufficiency.
Science Translational Medicine
, 14
(668)
, Article eabn5811. 10.1126/scitranslmed.abn5811.
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Glinos, DA;
Soskic, B;
Williams, C;
Kennedy, A;
Jostins, L;
Sansom, DM;
Trynka, G;
(2020)
Genomic profiling of T-cell activation suggests increased sensitivity of memory T cells to CD28 costimulation.
Genes & Immunity
10.1038/s41435-020-00118-0.
(In press).
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Halliday, N;
Williams, C;
Kennedy, A;
Waters, E;
Pesenacker, AM;
Soskic, B;
Hinze, C;
... Sansom, DM; + view all
(2020)
CD86 Is a Selective CD28 Ligand Supporting FoxP3+ Regulatory T Cell Homeostasis in the Presence of High Levels of CTLA-4.
Frontiers in Immunology
, 11
, Article 600000. 10.3389/fimmu.2020.600000.
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Hou, TZ;
Verma, N;
Wanders, J;
Kennedy, A;
Soskic, B;
Janman, D;
Halliday, N;
... Sansom, DM; + view all
(2017)
Identifying functional defects in patients with immune dysregulation due to LRBA and CTLA-4 mutations.
Blood
, 129
pp. 1458-1468.
10.1182/blood-2016-10-745174.
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Janman, D;
Hinze, C;
Kennedy, A;
Halliday, N;
Waters, E;
Williams, C;
Rowshanravan, B;
... Sansom, DM; + view all
(2021)
Regulation of CTLA-4 recycling by LRBA and Rab11.
Immunology
10.1111/imm.13343.
(In press).
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Kennedy, Alan;
Robinson, Maximillian A;
Hinze, Claudia;
Waters, Erin;
Williams, Cayman;
Halliday, Neil;
Dovedi, Simon;
(2023)
The CTLA-4 immune checkpoint protein regulates PD-L1:PD-1 interaction via transendocytosis of its ligand CD80.
The EMBO Journal
, Article e111556. 10.15252/embj.2022111556.
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Kennedy, Alan;
Waters, Erin;
Rowshanravan, Behzad;
Hinze, Claudia;
Williams, Cayman;
Janman, Daniel;
Fox, Thomas A;
... Sansom, David M; + view all
(2022)
Differences in CD80 and CD86 transendocytosis reveal CD86 as a key target for CTLA-4 immune regulation.
Nature Immunology
10.1038/s41590-022-01289-w.
(In press).
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Lax, Brianna M;
Palmeri, Joseph R;
Lutz, Emi A;
Sheen, Allison;
Stinson, Jordan A;
Duhamel, Lauren;
Santollani, Luciano;
... Wittrup, K Dane; + view all
(2023)
Both intratumoral regulatory T cell depletion and CTLA-4 antagonism are required for maximum efficacy of anti-CTLA-4 antibodies.
Proceedings of the National Academy of Sciences of the United States of America (PNAS)
, 120
(31)
, Article e2300895120. 10.1073/pnas.2300895120.
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Ovcinnikovs, V;
Ross, EM;
Petersone, L;
Edner, NM;
Heuts, F;
Ntavli, E;
Kogimtzis, A;
... Walker, LSK; + view all
(2019)
CTLA-4-mediated transendocytosis of costimulatory molecules primarily targets migratory dendritic cells.
Science Immunology
, 4
(35)
, Article eaaw0902. 10.1126/sciimmunol.aaw0902.
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Serwas, NK;
Hoeger, B;
Ardy, RC;
Stulz, SV;
Sui, Z;
Memaran, N;
Meeths, M;
... Boztug, K; + view all
(2019)
Human DEF6 deficiency underlies an immunodeficiency syndrome with systemic autoimmunity and aberrant CTLA-4 homeostasis.
Nature Communications
, 10
, Article 3106. 10.1038/s41467-019-10812-x.
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Slatter, MA;
Engelhardt, KR;
Burroughs, LM;
Arkwright, PD;
Nademi, Z;
Skoda-Smith, S;
Hagin, D;
... Torgerson, TR; + view all
(2016)
Hematopoietic stem cell transplantation for CTLA4 deficiency.
Journal of Allergy and Clinical Immunology
, 138
(2)
615-619.e1.
10.1016/j.jaci.2016.01.045.
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Soskic, B;
Jeffery, LE;
Kennedy, A;
Gardner, DH;
Hou, TZ;
Halliday, N;
Williams, C;
... Sansom, DM; + view all
(2020)
CD80 on Human T Cells Is Associated With FoxP3 Expression and Supports Treg Homeostasis.
Frontiers Immunology
, 11
, Article 577655. 10.3389/fimmu.2020.577655.
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Thomas, S;
Mohammed, F;
Reijmers, RM;
Woolston, A;
Stauss, T;
Kennedy, A;
Stirling, D;
... Stauss, HJ; + view all
(2019)
Framework engineering to produce dominant T cell receptors with enhanced antigen-specific function.
Nature Communications
, 10
(1)
, Article 4451. 10.1038/s41467-019-12441-w.
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Williams, Cayman;
Kennedy, Alan;
Robinson, Maximillian AA;
Lloyd, Christopher;
Dovedi, Simon JJ;
Sansom, David MM;
(2022)
Impact of CTLA-4 checkpoint antibodies on ligand binding and Transendocytosis.
Frontiers in Immunology
, 13
, Article 871802. 10.3389/fimmu.2022.871802.
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