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Number of items: 27.
Article
Andrews, Rebecca;
Fu, Bin;
Toomey, Christina E;
Breiter, Jonathan C;
Lachica, Joanne;
Beckwith, Joseph S;
Tian, Ru;
... Lee, Steven F; + view all
(2025)
Large-scale visualization of α-synuclein oligomers in Parkinson’s disease brain tissue.
Nature Biomedical Engineering
10.1038/s41551-025-01496-4.
(In press).
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Balligand, Thomas;
Carpenet, Claire;
Olivé Palau, Sergi;
Jaspers, Tom;
Suresh, Pavana;
Liu, Xin;
Medhi, Himadri;
... Dewilde, Maarten; + view all
(2025)
A pair of congenic mice for imaging of transplants by positron emission tomography using anti-transferrin receptor nanobodies.
eLife
, 14
, Article RP104302. 10.7554/eLife.104302.
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Boyanova, Sevda;
Banks, Gareth;
Lipina, Tatiana V;
Bains, Rasneer Sonia;
Forrest, Hamish;
Stewart, Michelle;
Carcolé, Mireia;
... Wiseman, Frances K; + view all
(2025)
Multi-modal comparative phenotyping of knock-in mouse models of frontotemporal dementia/amyotrophic lateral sclerosis.
Disease Models & Mechanisms
, 18
(8)
, Article dmm052324. 10.1242/dmm.052324.
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Cuypers, Marie-Lynn;
Jaspers, Tom;
Clerckx, Jarne;
Leekens, Simon;
Cawthorne, Christopher;
Bormans, Guy;
Cleeren, Frederik;
... Dewilde, Maarten; + view all
(2025)
Increasing brain half-life of antibodies by additional binding to myelin oligodendrocyte glycoprotein, a CNS specific protein.
Fluids and Barriers of the CNS
, 22
(1)
, Article 11. 10.1186/s12987-025-00624-1.
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De Strooper, Bart;
Haass, Christian;
Hardy, John;
Zetterberg, Henrik;
(2025)
The regulatory rollercoaster continues—EMA refuses donanemab.
The Lancet
, 405
(10492)
pp. 1810-1812.
10.1016/S0140-6736(25)00833-5.
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De Strooper, Bart;
Scheltens, Philip;
Salloway, Stephen;
(2025)
Breaking Barriers: Delivering Therapeutics to the Brain in Alzheimer’s
Disease.
The Journal of Prevention of Alzheimer's Disease
, 12
(7)
, Article 100229. 10.1016/j.tjpad.2025.100229.
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Farrell, C;
Buhidma, Y;
Mumford, P;
Heywood, WE;
Hällqvist, J;
Flores-Aguilar, L;
Andrews, EJ;
... Wiseman, FK; + view all
(2025)
Apolipoprotein E abundance is elevated in the brains of individuals with Down syndrome-Alzheimer's disease.
Acta Neuropathologica
, 149
(1)
, Article 49. 10.1007/s00401-025-02889-0.
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Fertan, Emre;
Hung, Christy;
Danial, John SH;
Lam, Jeff YL;
Preman, Pranav;
Albertini, Giulia;
English, Elizabeth A;
... Klenerman, David; + view all
(2025)
Clearance of beta-amyloid and tau aggregates is size dependent and altered by an inflammatory challenge.
Brain Communications
, 7
(1)
, Article fcae454. 10.1093/braincomms/fcae454.
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Fertan, Emre;
Lam, Jeff YL;
Albertini, Giulia;
Dewilde, Maarten;
Wu, Yunzhao;
Akingbade, Oluwatomi ES;
Böken, Dorothea;
... Klenerman, David; + view all
(2025)
Lecanemab preferentially binds to smaller aggregates present at early Alzheimer's disease.
Alzheimer's & Dementia
, 21
(4)
, Article e70086. 10.1002/alz.70086.
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Fowler, Stephanie L;
Behr, Tiana S;
Turkes, Emir;
O'Brien, Darragh P;
Cauhy, Paula Maglio;
Rawlinson, Isadora;
Edmonds, Marisa;
... Ryskeldi-Falcon, Benjamin; + view all
(2025)
Tau filaments are tethered within brain extracellular vesicles in Alzheimer's disease.
Nature Neuroscience
, 28
(1)
pp. 40-48.
10.1038/s41593-024-01801-5.
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Heneka, Michael T;
Van der Flier, Wiesje M;
Jessen, Frank;
Hoozemanns, Jeroen;
Thal, Dietmar Rudolf;
Boche, Delphine;
Brosseron, Frederic;
... Riechers, Sean-Patrick; + view all
(2025)
Neuroinflammation in Alzheimer disease.
Nature Reviews Immunology
, 25
pp. 321-352.
10.1038/s41577-024-01104-7.
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Jakabek, D;
Isaacs, AM;
De Strooper, B;
Tuszynski, M;
Lane, R;
Uspenskaya, O;
McDade, E;
... Mummery, CJ; + view all
(2025)
CTAD taskforce: genetic therapies in Alzheimer’s disease.
The Journal of Prevention of Alzheimer's Disease
, Article 100269. 10.1016/j.tjpad.2025.100269.
(In press).
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Kedia, S;
Fertan, E;
Wu, Y;
Zhang, YP;
Meisl, G;
Lam, JYL;
K. Wiseman, F;
... Klenerman, D; + view all
(2025)
SynPull: An advanced method for studying neurodegeneration-related aggregates in synaptosomes using super-resolution microscopy.
Cell Chemical Biology
, 32
(2)
338-351.e4.
10.1016/j.chembiol.2025.01.001.
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Morito, Takahiro;
Qi, Mohan;
Kamano, Naoko;
Sasaguri, Hiroki;
Bez, Sumi;
Foiani, Martha;
Duff, Karen;
... Watamura, Naoto; + view all
(2025)
Human MAPT knockin mouse models of frontotemporal dementia for the neurodegenerative research community.
Cell Reports: Methods
, 5
(4)
, Article 101024. 10.1016/j.crmeth.2025.101024.
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Murphy, Kitty B;
Hu, Di;
Wolfs, Leen;
Rohde, Susan K;
Fauro, Gonzalo Leguia;
Geric, Ivana;
Mancuso, Renzo;
... Marzi, Sarah J; + view all
(2025)
The APOE isoforms differentially shape the transcriptomic and epigenomic landscapes of human microglia xenografted into a mouse model of Alzheimer’s disease.
Nature Communications
, 16
, Article 4883. 10.1038/s41467-025-60099-4.
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Policarpo, Rafaela;
Wolfs, Leen;
Martinez-Montero, Saul;
Vandermeulen, Lina;
Royaux, Ines;
Van Peer, Gert;
Mestdagh, Pieter;
... d'Ydewalle, Constantin; + view all
(2025)
The MIR-NAT MAPT-AS1 does not regulate Tau
expression in human neurons.
PLoS ONE
, 20
(1)
, Article e0314973. 10.1371/journal.pone.0314973.
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Rifat, Ali;
Bickel, Tom;
Kreis, Patricia;
Trimbuch, Thorsten;
Onken, Julia;
Ivanov, Andranik;
Albertini, Giulia;
... Madry, Christian; + view all
(2025)
The chloride intracellular channel 1 (CLIC1) is essential for microglial morphodynamics and neuroinflammation.
Science Advances
, 11
(43)
, Article eads9181. 10.1126/sciadv.ads9181.
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Sanjuan-Ruiz, Inmaculada;
Serneels, Lutgarde;
Craessaerts, Katleen;
Goate, Alison;
Annaert, Wim;
Chávez-Gutiérrez, Lucía;
Shi, Yonggang;
... De Strooper, Bart; + view all
(2025)
The curious case of a heterozygous loss-of-function PSEN1 variant associated with early-onset Alzheimer’s disease.
Molecular Neurodegeneration Advances
, 1
, Article 4. 10.1186/s44477-025-00004-x.
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Serneels, Lutgarde;
Sierksma, Annerieke;
Pasciuto, Emanuela;
Geric, Ivana;
Nair, Arya;
Martinez-Muriana, Anna;
Snellinx, An;
(2025)
A versatile mouse model to advance human microglia transplantation research in neurodegenerative diseases.
Molecular Neurodegeneration volume
, 20
(1)
, Article 29. 10.1186/s13024-025-00823-2.
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Taddei, Raquel N;
Duff, Karen E;
(2025)
Synapse vulnerability and resilience across the clinical spectrum of dementias.
Nature Reviews Neurology
10.1038/s41582-025-01094-7.
(In press).
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Taddei, Raquel N;
Duff, Karen E;
(2025)
Synapse vulnerability and resilience underlying Alzheimer's disease.
eBioMedicine
, 112
, Article 105557. 10.1016/j.ebiom.2025.105557.
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Wu, Y;
Cleverley, K;
Wiseman, FK;
(2025)
Reduction of Cystatin B results in increased cathepsin B activity in disomic but not Trisomy 21 human cellular and mouse models.
PLoS ONE
, 20
(1)
, Article e0316822. 10.1371/journal.pone.0316822.
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Yang, Jie;
Yamashita-Kanemaru, Yumi;
Morris, Benjamin I;
Contursi, Annalisa;
Trajkovski, Daniel;
Xu, Jingru;
Patrascan, Ilinca;
... Roychoudhuri, Rahul; + view all
(2025)
Aspirin prevents metastasis by limiting platelet TXA2 suppression of T cell immunity.
Nature
10.1038/s41586-025-08626-7.
(In press).
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Thesis
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Blackburn, Emily Victoria;
(2025)
Investigating BDNF/TrkB signalling in neuronal models of Alzheimer's disease in Down syndrome.
Doctoral thesis (Ph.D), UCL(University College London).
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Desai, Perlina;
(2025)
Using proximity labelling to investigate astrocyte secretory pathway proteome alterations in Alzheimer's disease.
Doctoral thesis (Ph.D), UCL (University College London).
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Stuart, Skye;
(2025)
Modulating trans-synaptic tau transfer in vitro and in vivo.
Doctoral thesis (Ph.D), UCL (University College London).
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Wenz, Katharina;
(2025)
Investigating candidate genes for amyloid-β accumulation and toxicity in Alzheimer’s disease-Down syndrome.
Doctoral thesis (Ph.D), UCL (University College London).
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