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Collagen fibrils: Nanoscale ropes

Bozec, L; van der Heijden, G; Horton, M; (2007) Collagen fibrils: Nanoscale ropes. BIOPHYS J , 92 (1) 70 - 75. 10.1529/biophysj.106.085704. Green open access

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Abstract

The formation of collagen fibrils from staggered repeats of individual molecules has become "accepted'' wisdom. However, for over thirty years now, such a model has failed to resolve several structural and functional questions. In a novel approach, it was found, using atomic force microscopy, that tendon collagen fibrils are composed of subcomponents in a spiral disposition-that is, their structure is similar to that of macroscale ropes. Consequently, this arrangement was modeled and confirmed using elastic rod theory. This work provides new insight into collagen fibril structure and will have wide application-from the design of scaffolds for tissue engineering and a better understanding of pathogenesis of diseases of bone and tendon, to the conservation of irreplaceable parchment-based museum exhibits.

Type: Article
Title: Collagen fibrils: Nanoscale ropes
Open access status: An open access version is available from UCL Discovery
DOI: 10.1529/biophysj.106.085704
Publisher version: http://www.ncbi.nlm.nih.gov/pmc/ articles/PMC16978...
Keywords: MOLECULAR PACKING, DNA PLASMIDS, TENDON, ARRANGEMENT, MECHANICS
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Civil, Environ and Geomatic Eng
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > London Centre for Nanotechnology
URI: https://discovery.ucl.ac.uk/id/eprint/9832
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