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Investigating occipito-temporal contributions to reading with TMS

Duncan, KJ; Pattamadilok, C; Devlin, J; (2010) Investigating occipito-temporal contributions to reading with TMS. Journal of Cognitive Neuroscience , 22 (4) pp. 739-750. 10.1162/jocn.2009.21207. Green open access

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Abstract

The debate regarding the role of ventral occipito-temporal cortex (vOTC) in visual word recognition arises in part from difficulty delineating the functional contributions of vOTC as separate from other areas of the reading network. Here we investigated the feasibility of using transcranial magnetic stimulation (TMS) to interfere with vOTC processing in order to explore its specific contributions to visual word recognition. Three visual lexical d ecision experiments were conducted using neuro- navigated TMS. The first demonstrated that repetitive stimulation of vOTC successfully slowed word, but not non-word, responses. The second confirmed and extended these findings by demonstrating the effect was specific to vOTC and not present in the adjacent lateral occipital complex. The final experiment used paired-pulse TMS to investigate the time course of vOTC processing for words and revealed activation starting as early as 80-120msec post-stimulus onset – significantly earlier than that expected based on electrophysiological and magnetoencephalography studies. Taken together, these results clearly indicate that TMS can be successfully used to stimulate parts of vOTC previously believed to be inaccessible and provide a new tool for systematically investigating the information processing characteristics of vOTC. In addition, the findings provide strong evidence that lexical status and frequency significantly affect vOTC processing, findings difficult to reconcile with pre-lexical accounts of vOTC function.

Type: Article
Title: Investigating occipito-temporal contributions to reading with TMS
Open access status: An open access version is available from UCL Discovery
DOI: 10.1162/jocn.2009.21207
Publisher version: http://doi.org/10.1162/jocn.2009.21207
Language: English
Additional information: This version is the version of record. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: visual word recognition, fusiform gyrus, occipito-temporal sulcus
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Experimental Psychology
URI: https://discovery.ucl.ac.uk/id/eprint/98005
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