Pearson, R.;
Catsicas, M.;
Becker, D.;
Mobbs, P.;
(2002)
Purinergic and muscarinic modulation of the cell cycle and calcium signaling in the chick retinal ventricular zone.
The Journal of Neuroscience
, 22
(17)
pp. 7569-7579.
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Abstract
Spontaneous calcium transients occur in the ventricular zone of the chick retina and result from the endogenous release of neurotransmitters in the absence of action potentials. Calcium transients resulting from the activation of purinergic and muscarinic receptors occur in a mixed population of interphase and mitotic cells, whereas those produced by ionotropic GABA and glutamate receptors are mostly restricted to the interphase population, the GABA responses primarily coming from cells that express the neuronal marker TuJ-1. Muscarinic and purinergic receptors can act respectively as a brake and an accelerator on mitosis, whereas GABA and glutamate receptors are without effect. Our results suggest that the balance between muscarinic and purinergic activation acts to control the rate of retinal proliferation in early development.
| Type: | Article |
|---|---|
| Title: | Purinergic and muscarinic modulation of the cell cycle and calcium signaling in the chick retinal ventricular zone |
| Identifier: | PMID: 12196580 |
| Open access status: | An open access version is available from UCL Discovery |
| Publisher version: | http://www.jneurosci.org/cgi/content/abstract/22/1... |
| Language: | English |
| Additional information: | Published by the Society for Neuroscience This work is licensed under the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License. The license allows you to copy, distribute, and transmit the work, as well as adapting it. However, you must attribute the work to the author (but not in any way that suggests that they endorse you or your use of the work), and cannot use the work for commercial purposes without prior permission of the author. If you alter or build upon this work, you can distribute the resulting work only under the same or similar license to this one. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/ or send a letter to Creative Commons, 444 Castro Street, Suite 900, Mountain View, California, 94041, USA. |
| Keywords: | Glutamate, GABA, mitosis, chick embryo, eye, calcium signaling |
| URI: | https://discovery.ucl.ac.uk/id/eprint/9686 |
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