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CD133 (Prominin) negative human neural stem cells are clonogenic and tripotent.

Sun, Y; Kong, W; Falk, A; Hu, J; Zhou, L; Pollard, S; Smith, A; (2009) CD133 (Prominin) negative human neural stem cells are clonogenic and tripotent. PLoS One , 4 (5) , Article e5498. 10.1371/journal.pone.0005498. Green open access

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Abstract

CD133 (Prominin) is widely used as a marker for the identification and isolation of neural precursor cells from normal brain or tumor tissue. However, the assumption that CD133 is expressed constitutively in neural precursor cells has not been examined.

Type: Article
Title: CD133 (Prominin) negative human neural stem cells are clonogenic and tripotent.
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1371/journal.pone.0005498
Publisher version: http://dx.doi.org/10.1371/journal.pone.0005498
Language: English
Additional information: © 2009 Sun et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. PMCID: PMC2676510 The study was funded by European Commission projects, StemStroke and EuroSyStem, the Biotechnology and Biological Sciences Research Council and the Medical Research Council of the United Kingdom, the National Natural Science Foundation of China, the Scientific Research Foundation for the Returned Overseas Chinese Scholars, the State Education Ministry (China), and Shanghai Pujiang Program. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. AS is a Medical Research Council Professor.
Keywords: Animals, Antigens, CD, Antigens, CD15, Cell Line, Cell Proliferation, Clone Cells, Flow Cytometry, G0 Phase, G1 Phase, Gene Expression, Glycoproteins, Humans, Immunohistochemistry, Ki-67 Antigen, Neurons, Peptides, RNA, Messenger, Rats, Reverse Transcriptase Polymerase Chain Reaction, Stem Cells, Totipotent Stem Cells
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
URI: https://discovery.ucl.ac.uk/id/eprint/96098
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