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Cellular responses to external mechanical stimuli when seeded to 3D collagen

Karamichos, D; Brown, R; Mudera, V; (2005) Cellular responses to external mechanical stimuli when seeded to 3D collagen. In: European Cells and Materials. (pp. 60 - 60). Green open access

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Abstract

INTRODUCTION: Collagen is a naturally occurring visco-elastic protein and widely used biomaterial in Tissue engineering. Mechanical stimulation of cell seeded collagen constructs and its effects on cell orientation, intracellular signalling and molecular responses have been reported in literature2. Monitoring of cellular responses to mechanical stimulation include synthesis of active regulatory molecules such as growth factors or hormones, changes in matrix synthesis, cell alignment and enzyme release. The aim of this study was to investigate cellular responses to pre strained, stiffer and more organised collagen bio-artificial matrices.

Type: Proceedings paper
Title: Cellular responses to external mechanical stimuli when seeded to 3D collagen
Event: TCES (Tissue and Cell Engineering Society) meeting
Location: Queen Mary, University of London
Dates: 20 May 2005- 22 May 2005
Open access status: An open access version is available from UCL Discovery
Publisher version: http://www.ecmjournal.org/journal/supplements/vol0...
Language: English
Additional information: Reproduced with kind permission from eCM journal (www.ecmjournal.org)
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
URI: https://discovery.ucl.ac.uk/id/eprint/91889
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