Carpenter, JP;
Alpendurada, F;
Deac, M;
Maceira, A;
Garbowski, M;
Kirk, P;
Walker, JM;
... Pennell, DJ; + view all
(2010)
Right ventricular volumes and function in thalassemia major patients in the absence of myocardial iron overload.
Journal of Cardiovascular Magnetic Resonance
, 12
, Article 24. 10.1186/1532-429X-12-24.
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Abstract
Aim: We aimed to define reference ranges for right ventricular (RV) volumes, ejection fraction (EF) in thalassemia major patients (TM) without myocardial iron overload.Methods and results: RV volumes, EF and mass were measured in 80 TM patients who had no myocardial iron overload (myocardial T2* > 20 ms by cardiovascular magnetic resonance). All patients were receiving deferoxamine chelation and none had evidence of pulmonary hypertension or other cardiovascular comorbidity. Forty age and sex matched healthy non-anemic volunteers acted as controls. The mean RV EF was higher in TM patients than controls (males 66.2 +/- 4.1% vs 61.6 +/- 6%, p = 0.0009; females 66.3 +/- 5.1% vs 62.6 +/- 6.4%, p = 0.017), which yielded a raised lower threshold of normality for RV EF in TM patients (males 58.0% vs 50.0% and females 56.4% vs 50.1%). RV end-diastolic volume index was higher in male TM patients (mean 98.1 +/- 17.3 mL vs 88.4 +/- 11.2 mL/m(2), p = 0.027), with a higher upper limit (132 vs 110 mL/m(2)) but this difference was of borderline significance for females (mean 86.5 +/- 13.6 mL vs 80.3 +/- 12.8 mL/m(2), p = 0.09, with upper limit of 113 vs 105 mL/m(2)). The cardiac index was raised in TM patients (males 4.8 +/- 1.0 L/min vs 3.4 +/- 0.7 L/min, p < 0.0001; females 4.5 +/- 0.8 L/min vs 3.2 +/- 0.8 L/min, p < 0.0001). No differences in RV mass index were identified.Conclusion: The normal ranges for functional RV parameters in TM patients with no evidence of myocardial iron overload differ from healthy non-anemic controls. The new reference RV ranges are important for determining the functional effects of myocardial iron overload in TM patients.
| Type: | Article |
|---|---|
| Title: | Right ventricular volumes and function in thalassemia major patients in the absence of myocardial iron overload |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1186/1532-429X-12-24 |
| Publisher version: | http://dx.doi.org/10.1186/1532-429X-12-24 |
| Language: | English |
| Additional information: | © 2010 Carpenter et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| Keywords: | CARDIOVASCULAR MAGNETIC-RESONANCE, PULMONARY-ARTERY PRESSURE, BODY-SURFACE AREA, HEART-FAILURE, EJECTION FRACTION, BETA-THALASSEMIA, DIASTOLIC FUNCTION, INTERSTUDY REPRODUCIBILITY, GREAT-ARTERIES, SURVIVAL |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Haematology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science |
| URI: | https://discovery.ucl.ac.uk/id/eprint/91714 |
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