UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Placental gene therapy

David, AL; Ashcroft, R; (2009) Placental gene therapy. Obstetrics, Gynaecology & Reproductive Medicine , 19 (10) pp. 296-298. 10.1016/j.ogrm.2009.06.002. Green open access

[img]
Preview
Text
David and Ashcroft Placental Gene Therapy AAM.pdf

Download (202kB) | Preview

Abstract

Gene therapy uses genetic material as a drug delivery vehicle to express therapeutic proteins. Placental gene therapy may be useful for correction of two important obstetric conditions, foetal growth restriction and pre-eclampsia in which there is a failure of the physiological trophoblast remodelling of the uterine spiral arteries in early pregnancy. The patient in this scenario is the foetus. Placental gene therapy might be justifiable when: there is reasonable certainty that the foetus will suffer irreversible and substantial harm without the intervention; the intervention is safe and effective; the risk to the health of the mother is negligible; and the mother can give informed consent to the intervention.

Type: Article
Title: Placental gene therapy
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.ogrm.2009.06.002
Publisher version: http://dx.doi.org/10.1016/j.ogrm.2009.06.002
Language: English
Additional information: Copyright © 2009 Elsevier Ltd. All rights reserved. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/. The published version of record is available at http://dx.doi.org/10.1016/j.ogrm.2009.06.002
Keywords: foetal therapy; gene therapy; medical ethics; placenta
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health > Maternal and Fetal Medicine
URI: https://discovery.ucl.ac.uk/id/eprint/83220
Downloads since deposit
62Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item