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Time course of functional connectivity between dorsal premotor and contralateral motor cortex during movement selection

Koch, G.; Franca, M.; Del Olmo, M.F.D.; Cheeran, B.; Milton, R.; Sauco, M.A.; Rothwell, J.C.; (2006) Time course of functional connectivity between dorsal premotor and contralateral motor cortex during movement selection. Journal of Neuroscience , 26 (28) pp. 7452-7459. 10.1523/JNEUROSCI.1158-06.2006. Green open access

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Abstract

The left dorsal premotor cortex (PMd) is thought to play a dominant role in the selection of movements made by either hand. We used transcranial magnetic stimulation to study the functional connectivity of the left PMd and right primary motor cortex (M1) during an acoustic choice reaction time (RT) task involving contraction of the thumb and forefinger. The facilitatory and inhibitory pathways that can be demonstrated between left PMd and right M1 at rest were suppressed during most of the reaction period. However, they were activated briefly at the start of the reaction period, depending on whether the cue indicated that the forthcoming movement had to be made with the left or the right hand. The facilitatory pathway was active at 75 ms in those trials in which the subjects were required to move the left hand, whereas the inhibitory pathway was active at 100 ms in trials in which the subjects had to move the right hand. These changes in excitability did not occur in hand muscles not used in the task. There were no significant changes in the excitability of intracortical circuits [short intracortical inhibition (SICI) and intracortical facilitation (ICF)] in the right M1. Interhemispheric interactions between the right PMd and left M1 were mainly inhibitory at rest and showed the same temporal profile of interhemispheric inhibition as for left PMd–right M1, although no evidence was found for facilitatory interactions. The results illustrate the importance of PMd not only in facilitating cued movements but also in suppressing movements that have been prepared but are not used.

Type: Article
Title: Time course of functional connectivity between dorsal premotor and contralateral motor cortex during movement selection
Open access status: An open access version is available from UCL Discovery
DOI: 10.1523/JNEUROSCI.1158-06.2006
Publisher version: http://dx.doi.org/10.1523/JNEUROSCI.1158-06.2006
Language: English
Additional information: This work is licensed under the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License. The license allows you to copy, distribute, and transmit the work, as well as adapting it. However, you must attribute the work to the author (but not in any way that suggests that they endorse you or your use of the work), and cannot use the work for commercial purposes without prior permission of the author. If you alter or build upon this work, you can distribute the resulting work only under the same or similar license to this one. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/ or send a letter to Creative Commons, 444 Castro Street, Suite 900, Mountain View, California, 94041, USA.
Keywords: Premotor cortex, transcranial magnetic stimulation, paired TMS, corticocortical connectivity, movement selection, time
UCL classification: UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Department of Neuromuscular Diseases
URI: https://discovery.ucl.ac.uk/id/eprint/7789
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