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Deciphering interplay between Salmonella invasion effectors.

Cain, RJ; Hayward, RD; Koronakis, V; (2008) Deciphering interplay between Salmonella invasion effectors. PLoS Pathog , 4 (4) , Article e1000037. 10.1371/journal.ppat.1000037. Green open access

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Abstract

Bacterial pathogens have evolved a specialized type III secretion system (T3SS) to translocate virulence effector proteins directly into eukaryotic target cells. Salmonellae deploy effectors that trigger localized actin reorganization to force their own entry into non-phagocytic host cells. Six effectors (SipC, SipA, SopE/2, SopB, SptP) can individually manipulate actin dynamics at the plasma membrane, which acts as a 'signaling hub' during Salmonella invasion. The extent of crosstalk between these spatially coincident effectors remains unknown. Here we describe trans and cisbinary entry effector interplay (BENEFIT) screens that systematically examine functional associations between effectors following their delivery into the host cell. The results reveal extensive ordered synergistic and antagonistic relationships and their relative potency, and illuminate an unexpectedly sophisticated signaling network evolved through longstanding pathogen-host interaction.

Type: Article
Title: Deciphering interplay between Salmonella invasion effectors.
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1371/journal.ppat.1000037
Publisher version: http://dx.doi.org/10.1371/journal.ppat.1000037
Language: English
Additional information: © 2008 Cain et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Funding: This work was supported by a Wellcome Trust Programme grant (VK) and a Medical Research Council Studentship (RJC). RDH is a Royal Society University Research Fellow.
Keywords: Actins, Animals, Bacterial Proteins, Calcium-Binding Proteins, Cell Membrane, Cytoskeleton, Host-Pathogen Interactions, Mice, Microfilament Proteins, NIH 3T3 Cells, Phosphatidylinositols, Salmonella typhimurium, Signal Transduction
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
URI: https://discovery.ucl.ac.uk/id/eprint/76176
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