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Influence of leptin on arterial distensibility - A novel link between obesity and cardiovascular disease?

Singhal, A; Farooqi, IS; Cole, TJ; O'Rahilly, S; Fewtrell, M; Kattenhorn, M; Lucas, A; (2002) Influence of leptin on arterial distensibility - A novel link between obesity and cardiovascular disease? CIRCULATION , 106 (15) 1919 - 1924. 10.1161/01.CIR.0000033219.24717.52. Green open access

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Abstract

Background-The mechanisms by which obesity increases the risk of atherosclerotic cardiovascular disease (CVD) are poorly understood. In experimental models, leptin, a hormone produced by adipose tissue, has been shown adversely to affect vascular health. Therefore, we tested the hypothesis that high leptin concentrations are associated with lower arterial distensibility, an index of circulatory function relevant to the atherosclerotic process.Methods and Results-Noninvasive, high-resolution, vascular ultrasound was used to measure brachial artery distensibility in 294 healthy adolescents (aged 13 to 16 years) who had a broad range of body mass indexes. Fat mass was measured by bioelectric impedance analysis; fasting serum leptin concentration by radioimmunoassay; and lipid profile, fasting insulin, glucose, and C-reactive protein concentrations by standard laboratory techniques. Higher leptin concentrations were associated with impaired arterial distensibility (regression coefficient, -1.3% change in arterial distension per 10% increase in leptin; 95% CI, -1.9% to -0.8%; P<0.001). This association was independent of fat mass, blood pressure, and C-reactive protein, fasting insulin, or LDL cholesterol concentrations.Conclusions-Elevation in leptin was associated with impaired vascular function, independent of the metabolic and inflammatory disturbances associated with obesity. Our observations are consistent with data from experimental models and suggest that high leptin concentration is an important mechanism for the adverse influence of body fatness on CVD.

Type: Article
Title: Influence of leptin on arterial distensibility - A novel link between obesity and cardiovascular disease?
Open access status: An open access version is available from UCL Discovery
DOI: 10.1161/01.CIR.0000033219.24717.52
Keywords: atherosclerosis, obesity, cardiovascular diseases, COMMON CAROTID-ARTERY, PULSE-WAVE VELOCITY, MYOCARDIAL-INFARCTION, BLOOD-PRESSURE, FOLLOW-UP, CHILDREN, RISK, FAT, ATHEROSCLEROSIS, STIFFNESS
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Cardiovascular Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Cardiovascular Science > Clinical Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > UCL GOS Institute of Child Health > ICH Pop, Policy and Practice Prog
URI: https://discovery.ucl.ac.uk/id/eprint/7464
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