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Analysis of the Changes in the Oxidation of Brain Tissue Cytochrome-c-Oxidase in Traumatic Brain Injury Patients during Hypercapnoea A Broadband NIRS Study

Tachtsidis, I; Tisdall, MM; Pritchard, C; Leung, TS; Ghosh, A; Elwell, CE; Smith, M; (2011) Analysis of the Changes in the Oxidation of Brain Tissue Cytochrome-c-Oxidase in Traumatic Brain Injury Patients during Hypercapnoea A Broadband NIRS Study. In: LaManna, JC and Puchowicz, MA and Xu, K and Harrison, DK and Bruley, DF, (eds.) Oxygen Transport to Tissue XXXII. (pp. 9 - 14). Springer Verlag: Berlin/ Heidelberg, Germany. Green open access

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Abstract

Using broadband near-infrared spectroscopy (NIRS) and cerebral micro-dialysis (MD), we investigated cerebral cellular metabolism and mitochondrial redox states, following hypercapnoea in 6 patients with traumatic brain injury (TBI). In all patients hypercapnoea increased intracranial pressure and cerebral blood flow velocity measured with transcranial Doppler. Despite the likely increase in cerebral oxygen delivery, we did not see an increase in the oxidation status of cytochrome-c-oxidase [oxCCO] in every patient. Analysis of the NIRS data demonstrated two patterns of the changes; Group A (n = 4) showed an increase in [oxCCO] of 0.34(+/-0.34)mu M and Group B (n = 2) a decrease of 0.40(+/- 0.41)mu M. Although no obvious association was seen between the Delta[oxCCO] and the MD, measured changes in lactate and pyruvate concentrations. Further work using model informed data interpretation may be helpful in understanding the multimodal signals acquired in this heterogeneous patient group.

Type: Proceedings paper
Title: Analysis of the Changes in the Oxidation of Brain Tissue Cytochrome-c-Oxidase in Traumatic Brain Injury Patients during Hypercapnoea A Broadband NIRS Study
Event: 37th Annual Meeting of the International Society on Oxygen Transport to Tissue (ISOTT)
Location: Cleveland, OH, US
Dates: 5 - 9 July, 2009
ISBN-13: 97814419775642
Open access status: An open access version is available from UCL Discovery
DOI: 10.1007/978-1-4419-7756-4_2
Publisher version: http://dx.doi.org/10.1007/978-1-4419-7756-4_2
Language: English
Additional information: © 2011 Springer Verlag. The original publication is available at www.springerlink.com
Keywords: Carbon-dioxide, blood-flow, metabolism, microdialysis, spectroscopy, tomography, hyperoxia
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng
URI: https://discovery.ucl.ac.uk/id/eprint/73894
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