UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Prevention of arthritis by interleukin 10-producing B cells

Mauri, C.; Gray, D.; Mushtaq, N.; Londei, M.; (2003) Prevention of arthritis by interleukin 10-producing B cells. Journal of Experimental Medicine , 197 (4) pp. 489-501. 10.1084/jem.20021293. Green open access

[thumbnail of 7089.pdf]

Download (227kB)


In this study we have shown that activation of arthritogenic splenocytes with antigen and agonistic anti-CD40 gives raise to a B cell population that produce high levels of interleukin (IL)-10 and low levels of interferon (IFN)-{gamma}. Transfer of these B cells into DBA/1-TcR-ß-Tg mice, immunized with bovine collagen (CII) emulsified in complete Freund's adjuvant inhibited T helper type 1 differentiation, prevented arthritis development, and was also effective in ameliorating established disease. IL-10 is essential for the regulatory function of this subset of B cells, as the B cells population isolated from IL-10 knockout mice failed to mediate this protective function. Furthermore, B cells isolated from arthritogenic splenocytes treated in vitro with anti–IL-10/anti–IL-10R were unable to protect recipient mice from developing arthritis. Our results suggest a new role of a subset of B cells in controlling T cell differentiation and autoimmune disorders.

Type: Article
Title: Prevention of arthritis by interleukin 10-producing B cells
Open access status: An open access version is available from UCL Discovery
DOI: 10.1084/jem.20021293
Publisher version: http://dx.doi.org/10.1084/jem.20021293
Language: English
Keywords: Autoimmunity, immunoregulation, B cells, interleukin 10, CD40
UCL classification: UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inflammation
URI: https://discovery.ucl.ac.uk/id/eprint/7089
Downloads since deposit
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item