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Auditory neuropathy in a patient exposed to xylene: case report

Draper, THJ; Bamiou, DE; (2009) Auditory neuropathy in a patient exposed to xylene: case report. Journal of Laryngology and Otology , 123 (4) 462 - 465. 10.1017/S0022215108002399. Green open access

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Abstract

Objective: To report the case of an adult patient who developed auditory complaints following xylene exposure, and to review the literature on the effects of solvent exposure on hearing.Case report: The patient presented with a gradual deterioration in his ability to hear in difficult acoustic environments and also to hear complex sounds such as music, over a 40-year period. His symptoms began following exposure to the solvent xylene, and in the absence of any other risk factor. Our audiological investigations revealed normal otoacoustic emissions with absent auditory brainstem responses and absent acoustic reflexes in both ears, consistent with a diagnosis of bilateral auditory neuropathy. Central test results were also abnormal, indicating possible involvement of the central auditory pathway.Conclusions: To our knowledge, this is the first report of retrocochlear hearing loss following xylene exposure. The test results may provide some insight into the effect of xylene as an isolated agent on the human auditory pathway.

Type: Article
Title: Auditory neuropathy in a patient exposed to xylene: case report
Open access status: An open access version is available from UCL Discovery
DOI: 10.1017/S0022215108002399
Publisher version: http://dx.doi.org/10.1017/S0022215108002399
Language: English
Additional information: Copyright Cambridge University Press 2008
Keywords: Auditory neuropathy, Hearing, Xylene, Solvent exposure, Hearing-loss, Otoneurological findings, Industrial solvents, Workers, Neurotoxicity, Styrene, Noise
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > The Ear Institute
URI: https://discovery.ucl.ac.uk/id/eprint/70543
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